Registration Dossier
Registration Dossier
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EC number: 209-952-3 | CAS number: 598-78-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from Literature without sufficient experimental details.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline or method is referenced.
- GLP compliance:
- not specified
- Test type:
- other: Acute method but no additional data presented
Test material
- Reference substance name:
- 2-chloropropionic acid
- EC Number:
- 209-952-3
- EC Name:
- 2-chloropropionic acid
- Cas Number:
- 598-78-7
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- 2-chloropropanoic acid
- Details on test material:
- No additional details on the test material presented
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No additional data presented
Administration / exposure
- Route of administration:
- other: No data presented
- Vehicle:
- not specified
- Details on oral exposure:
- No additional data presented
- Doses:
- No additional data presented
- No. of animals per sex per dose:
- No additional data presented
- Control animals:
- not specified
- Details on study design:
- No additional data presented
- Statistics:
- No additional data presented
Results and discussion
- Preliminary study:
- No information on any preliminary study reported
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
- Remarks on result:
- other: Rat
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 400 mg/kg bw
- Remarks on result:
- other: This test was conducted on mice
- Mortality:
- No additional data presented
- Clinical signs:
- other: No additional data presented
- Gross pathology:
- No additional data presented
- Other findings:
- No additional data presented
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: harmful
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for 2-chloropropionic acid in male rats is reported as 800 mg/kg. In mice the LD50 is reported as 400 mg/kg/bw. This would result in a harmful classification under the EU system with the risk phrase R22, Harmful if swallowed and Acute Toxicity Category 4 under CLP.
- Executive summary:
The Toxnet website ( http://toxnet.nlm.nih.gov/ ) entry for 2 -chloropropionic acid contains a number of references to the American Conference of Governmental Industrial Hygienists(ACGIH). This is a professional association of industrial hygienists and practitioners of related professions.
With regard to acute toxicity, the LD50 in male rats is reported to be 800 mg/kg bw and in male mice is reported to be 400 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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