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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Reaction mass of (E)-1-chlorobut-2-ene and 3-chlorobut-1-ene
EC Number:
908-820-9
Molecular formula:
not applicable
IUPAC Name:
Reaction mass of (E)-1-chlorobut-2-ene and 3-chlorobut-1-ene
Details on test material:
Details on Test material
- Name of test material (as cited in study report): Crotylchlorid
- Substance type: clear liquid
- Physical state: liquid
- Analytical purity: > 97.5%

Radiolabelling:
no

Study design

Analytical monitoring:
yes
Buffers:
- Composition of buffer:
a) pH 4: citric acid - sodium hydroxide - hydrochloric acid
b) pH 7: potassium dihydrogen phosphate - disodium hydrogen phosphate
c) pH 9: boric acid - potassium chloride - sodium hydroxide
The buffers were diluted (1:2) with purified water.
for further details see company report 2009-0026-DGO
Details on test conditions:
for further details see company report 2009-0026-DGO
Duration of testopen allclose all
Duration:
0 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
296 mg/L
Duration:
1 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
29 mg/L
Duration:
4 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
1 mg/L
Duration:
0 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
299 mg/L
Duration:
1 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
4 mg/L
Duration:
4 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
2 mg/L
Duration:
0 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
354 mg/L
Duration:
1 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
59 mg/L
Duration:
4 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
< 1 mg/L
Positive controls:
no
Negative controls:
no

Results and discussion

Preliminary study:
both components showed at each pH value high reactivity with water (t 1/2 < 1 hour) at 50°C.
Test performance:
main test was not performed because of the high reactivity with water.
Transformation products:
not measured
Total recovery of test substance (in %)open allclose all
% Recovery:
9.8
pH:
4
Temp.:
50 °C
Duration:
1 h
% Recovery:
0.3
pH:
4
Temp.:
50 °C
Duration:
4 h
% Recovery:
1.3
pH:
7
Temp.:
50 °C
Duration:
1 h
% Recovery:
0.7
pH:
7
Temp.:
50 °C
Duration:
4 h
% Recovery:
16.7
pH:
9
Temp.:
50 °C
Duration:
1 h
% Recovery:
< 0.3
pH:
9
Temp.:
50 °C
Duration:
4 h
Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
Hydrolysis rate constant:
0.69 d-1
DT50:
< 1 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: k rate estimated as upper limit
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
0.69 d-1
DT50:
< 1 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: k rate estimated as upper limit
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0.69 d-1
DT50:
< 1 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: k rate estimated as upper limit

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The main test was not necessary because of a half lifetime < 2.4 hours (at 50°C) or less one day at 25°C.