Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Explosiveness
Administrative data
- Endpoint:
- explosive properties of explosives
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16/06/2021 - 24/06/2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.14 (Explosive properties)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
- Cas Number:
- 1903009-55-1
- Molecular formula:
- C27H30N8O4
- IUPAC Name:
- 4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
Batch (Lot) Number: I20HD2581
Purity: 97.1%
Purity/Composition correction factor: 1.00
Expiry date: 15 August 2022
Physical Description: Yellow powder
STORAGE CONDITIONS
Storage Conditions: At room temperature
Results and discussion
Small-scale preliminary testsopen allclose all
- Key result
- Parameter:
- sensitiveness to impact: impact energy (J)
- Remarks on result:
- not sensitive to impact using an impact energy of 40 J
- Remarks:
- The test item was observed to exhibit no reaction at 40J
- Key result
- Parameter:
- sensitiveness to friction: friction load (N)
- Remarks on result:
- not sensitive to friction using a friction load of 360 N
- Remarks:
- The test item was observed to exhibit no reaction at 360 N
- Key result
- Parameter:
- thermal sensitivity - Koenen test: diameter of the orifice plate
- Remarks on result:
- not thermal sensitive if heated under defined confinement
- Remarks:
- The test item did not exhibit an explosion during any of the tests.
Any other information on results incl. tables
- BAM FALLHAMMER: Test Procedure
The test item was placed in the impact device and the 10 kg weight dropped from a height of 40 cm which is equivalent to 40 J. If an "explosion" was observed, the impact energy was reduced to 7.5 J and further tests conducted.
| Mass (kg) | Height (m) | Energy (J) | Test number and result* (X / ✓) | Comments |
| 10 | 0.4 | 40 | 1 2 3 4 5 6 X X X X X X | Decomposition observed (changed to orange colour) |
* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).
2. BAM FRICTION: Test procedure
The test item was placed on the porcelain plate and the peg lowered. A load of 360 N was then applied and the switch operated. If an "explosion" was observed, the load applied was lowered to 120 N and further tests conducted.
| Mass (kg) | Load (N) | Test number and result* (X / ✓) | Comments |
| 10 | 360 | 1 2 3 4 5 6 X X X X X X | Decomposition (changed to dark yellow colour) |
* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).
3. KOENEN TUBE: Test procedure
| Mass of test item (g) | Orifice Diameter (mm) | Time for First Ignition (s) | Explosion (X✓)* |
| 13.3 | 6 | 15 | X |
| 13.3 | 6 | 16 | X |
| 13.3 | 6 | 14 | X |
| 13.3 | 2 | 13 | X |
| 13.3 | 2 | 12 | X |
| 13.3 | 2 | 12 | X |
* ‘✓’ denotes 3 or more fragments.
‘X’ denotes fewer than 3 fragments.
Applicant's summary and conclusion
- Conclusions:
- BAM FALLHAMMER:
The test item of JNJ-73848268-AAA (T003903) was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).
BAM FRICTION:
The test item of JNJ-73848268-AAA (T003903) was observed to exhibit no reaction at 360 N. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).
KOENEN TUBE:
The test item did not exhibit an explosion during any of the tests. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).
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