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EC number: 419-050-3 | CAS number: 79944-37-9 AMINODIOXEPAN
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 92/69
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- HPLC
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: To produce the test concentration, 55.55 mg of the test substance were dissolved in 500 ml tap water.
- Controls: yes, 4 replicates - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Age at study initiation (mean and range, SD): 0-24 h
- Stage and instar at study initiation: Neonates
- Source: Schering AG, Experimental Toxicology
ACCLIMATION
- Acclimation period: Parent animals were kept in glass vessels in water of the same quality and temperature as under experimental conditions.
- Acclimation conditions (same as test or not): same as test conditions - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 19.9 - 20.6 °C
- pH:
- 7.7 - 8.5
- Dissolved oxygen:
- 7.8 - 8.9 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Measured concentration: 93-94% of nominal concentration - Details on test conditions:
- TEST SYSTEM
- Test vessel: each test vessel was filled with 50 mL test solution
- Material, size, headspace, fill volume: fill volume of the test vessels was 100 mL
- No. of organisms per vessel: 5 animals
- No. of vessels per concentration (replicates): 4 replicates
- No. of vessels per control (replicates): 4 replicates
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Normal tap water was used as dilution water, not polluted with harmful concentrations of chlorine, heavy metals or other substances, based on quarterly measurements.
- Culture medium different from test medium: no
- Intervals of water quality measurement: quarterly measurements and in accordance with the "Trinkwasserverordnung"
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: light/dark rhythm 12/12 h
EFFECT PARAMETERS MEASURED
- immobilization was recorded after 24 and 48 h - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: no
- Immobilisation of control: no - Validity criteria fulfilled:
- yes
- Remarks:
- See 'Any other information on results incl. tables'.
- Conclusions:
- No toxic effect of the test substance against Daphnia up to 100 mg/L (nominal concentration) was observed; EC50(48h)>100 mg/L (nominal, equivalent to 93.5 mg/L measured) .
- Executive summary:
The study was performed to assess the acute toxicity of the test substance to Daphnia magna under static conditions. The study was conducted in accordance with 92/69/EEC Part C, Method 2 'Acute toxicity for Daphnia' and the OECD Guideline for Testing of Chemicals No. 202 'Daphnia sp., Acute Immobilisation Test and Reproduction Test, Part I- The 24h EC50 Acute Immobilisation Test'. The Daphnia were exposed to a limit test concentration of nominally 100 mg/L of the test substance dissolved in water. Observations were made on the immobilisation of Daphnids after 24 and 48 hours of exposure. The following values were determined: EC50(48h)>100 mg/L nominal concentration (equivalent to 93.5 mg/L). Recovery rates correspond to 93% of nominal value at 0 hours and to 94% of nominal value at 48 hours.
Reference
Validity criteria for the measurement of the daphnia toxicity
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
In the control, including the solubilising agent, not more than 10 % of the daphnids should have been immobilized. (Not more than 10 % of the control daphnids should show immobilisation or other signs of disease or stress, for example, discoloration or unusual behaviour such as trapping at surface of water) | Immobilization of control: 0% | Yes |
The dissolved oxygen concentration at the end of the test should be >/= 3 mg/L in control and test vessels. | Dissolved oxygen concentration was 8.6 mg/L in control and test vessels. | Yes |
The concentration of the test item shall be maintained to within 80% of the initial concentration throughout the study. The maintenance of concentration is proved by analytical measurements | Recovery rates correspond to 93% of nominal value at 0 hours and to 94% of nominal value at 48 hours. | Yes |
A limit test may be performed at 100 mg/L of the test substance in order to demonstrate that the EC50 is greater than this concentration. The limit test should be performed using 20 daphnids, with the same number in the control. If the percentage of immobilisation exceeds 10% at the end of the test, a full study chould be conducted. | Within the limit test, 20 daphnids were used for the test concentration of 100 mg/L (4 replicates and 5 daphnia per test vessel) and 20 daphnids for the control (4 replicates and 5 daphnia per test vessel). No immobilization of daphnids was observed within the test. | Yes |
Description of key information
The study was performed to assess the acute toxicity of the test substance to Daphnia magna under static conditions. The study was conducted in accordance with 92/69/EEC Part C, Method 2 'Acute toxicity for Daphnia' and the OECD Guideline for Testing of Chemicals No. 202 'Daphnia sp., Acute Immobilisation Test and Reproduction Test, Part I- The 24h EC50 Acute Immobilisation Test'. The Daphnia were exposed to a limit test concentration of nominally 100 mg/L of the test substance dissolved in water. Observations were made on the immobilisation of Daphnids after 24 and 48 hours of exposure. The following values were determined: EC50 (48 h)>100 mg/L nominal concentration (equivalent to 93.5 mg/L). Recovery rates correspond to 93% of nominal value at 0 hours and to 94% of nominal value at 48 hours.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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