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Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2022-01-11 to 2022-03-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 113

Version / remarks:

1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

dynamic method

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

9 hPa

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

12.8 hPa

Test no.:

#3

Temp.:

50 °C

Vapour pressure:

63.7 hPa

Thermal stability (DSC):

The test item (4.80 mg) showed an exothermic effect starting at a temperature of 180 °C with an energy release of -60 J/g.

Dynamic Method: Vapour-Liquid Equilibrium (VLE):

The vapour pressure was measured in the temperature range of 39.2 °C to 82.5 °C. The measured vapour pressure values and the corresponding measured temperatures are summarised in Table 1.

Table 1: Results of the dynamic method

Measurement	Temperature [°C]	Vapour pressure [hPa]	Remark
1	39.2	30	Measured up
2	55.9	100	Measured up
3	63.9	148	Measured up
4	69.8	200	Measured up
5	75.4	250	Measured up
6	82.5	350	Measured up
7	80.2	324	Measured down
8	79.1	301	Measured down
9	72.5	225	Measured down

From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation were derived.

The vapour pressures of the test item were calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C.

Conclusions:

The vapour pressure of the test item is as follows:
20 °C: 9.0 hPa
25 °C: 12.8 hPa
50 °C: 63.7 hPa

Executive summary:

In a GLP study, according to EU Method A.4. and OECD Test Guideline 104, the vapour pressure of the test item was calculated by interpolation and extrapolation of the measured vapour pressures for the temperatures 20 °C, 25 °C and 50 °C  as follows:

20 °C: 9.0 hPa

25 °C: 12.8 hPa

50 °C: 63.7 hPa

Description of key information

In a GLP study, according to EU Method A.4. and OECD Test Guideline 104, the vapour pressure of the test item was calculated by interpolation and extrapolation of the measured vapour pressures for the temperatures 20 °C, 25 °C and 50 °C as follows:

20 °C: 9.0 hPa

25 °C: 12.8 hPa

50 °C: 63.7 hPa

Key value for chemical safety assessment

Vapour pressure:

9 hPa

at the temperature of:

20 °C