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EC number: 473-690-8 | CAS number: 738602-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar - Jun 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- -
- EC Number:
- 473-690-8
- EC Name:
- -
- Cas Number:
- 738602-93-2
- Molecular formula:
- not applicable for UVCB
- IUPAC Name:
- (2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (2S,3R,5R)-4-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: Sponsor, Batch 4G08
- Purity, including information on contaminants, isomers, etc.: 54.2 % Maltotriosyl glucoside
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature at about 20 °C away from direct sunlight
Study design
- Test temperature:
- 25 °C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Merck-Hitachi pump L-6200
Merck-Hitachi autosampler L-7450
Merck-Hitachi UV/Vis detector L-4000
Sedex ELSD detector 85
Jones Column oven 7990
- Type: HPLC
- Type, material and dimension of analytical (guard) column: Lichrospher 100 CN, pre-column CN
- Detection system: UV VIS, ELSD
MOBILE PHASES
- Type: water/methanol (45:55 v/v%)
- Experiments with additives carried out on separate columns: no
- pH: 6.8
- Solutes for dissolving test and reference substances:
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (sodium nitrate)
REFERENCE SUBSTANCES
- Identity: isoproturon, linuron, 2,4-DDT, diclofop-methyl, acetanilide, pyrazophos
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 8.23 µg/ml, 100 µl
- Quantity of reference substances:
isoproturon 10.64 mg, 135 µl
linuron, 10.53 mg, 55 µl
2,4-DDT, 13.05 mg, 250 µl
diclofop-methyl, 10.56 mg 180 µl
acetanilide, 10.83 mg, 140 µl
pyrazophos 20.97 mg 800 µl
dilute to 10 mL with mobile phase,
100 µl injected
- Intervals of calibration: 6
REPETITIONS
- Number of determinations: 3
EVALUATION
- Calculation of capacity factors k': calculated from the retention time of the reference items, the test item and an un-retarded item
- Calculation of retention times: no specific calculation
- Determination of the log Koc value: by linear regression
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- 0.32
- pH:
- 6.8
- Temp.:
- 25 °C
- Key result
- Sample No.:
- #2
- Type:
- Koc
- Value:
- 0.304
- pH:
- 6.8
- Temp.:
- 25 °C
- Key result
- Sample No.:
- #3
- Type:
- Koc
- Value:
- 0.393
- pH:
- 6.8
- Temp.:
- 25 °C
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration (min):
Acetanilide 3.12
Isoproturon 3.63
Linuron 4.58
Pyrazophos 5.91
Dicolfop-methyl 6.91
2,4-DDT 10.67
- Details of fitted regression line (log k' vs. log Koc):
Y = a+b*x
Y = log k' values
X = log Koc values
b = 0.162
a=-0.051
r = 0.999
- Average retention data for test substance: 2.23 min
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, the log of the adsorption coefficient of MG-60 was estimated to be log Koc -0.5 which is equal to a Koc value of 0.3 using the HPLC method. This value indicates that MG-60 will not be adsorbed by organic carbon in soil. MG-60 is very mobile.
- Executive summary:
The determination of the adsorption coefficient (Koo) of MG-60 was performed according to the OECD Guideline for the Testing of Chemicals, No. 121, Estimation of the Adsorption Coefficient (Koo) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), January, 2001 and the EC Directive 2001/59, C.19.
The test item solution was injected three times and the combined reference solution was injected six times. The test item is not UV detectable. Therefore, ELSD was used for the detection. Only three of the reference compounds (isoproturon, pyrazophos and diclofop- methyl) were ELSD detectable. Therefore, the ELSD signal of the test item was corrected using a time increment A t, to adjust for the time difference between UV and ELSD detection times. This time increment was determined with isoproturon, pyrazophos and diclofop-methyl.
The retention time of the test item was determined to be below the lowest reference item used (acetanilide). Thus, the log Koc of MG-60 was determined to be < 1.25. By extrapolating the regression curve, the log Koc of the test item was calculated to be -0.5, corresponding to a Koc value of 0.3.
In the present study the reference items covered the range of log Koc 1.25 to log Koc 5.63.The chromatography of the test item resulted in one main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, MG-60 was considered to be stable during the test procedure.
The retention times of the individual measurements of the reference items, test item and the dead time are reported. The capacity factor (k') was calculated for each reference item using the retention times. Log KOc was plotted versus log k for each component to obtain a regression curve.
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