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EC number: 838-724-1 | CAS number: 94568-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Jul - 21 Aug 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- GLP compliance unknown, minor deviations from guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- adopted 17 Dec 2001
- Deviations:
- yes
- Remarks:
- - Animals should be 8-12 weeks old, but were 7 weeks old - No information on sighting study
- GLP compliance:
- not specified
- Remarks:
- in-house safety study
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine
- EC Number:
- 838-724-1
- Cas Number:
- 94568-76-0
- Molecular formula:
- C12H17N
- IUPAC Name:
- 1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Japan Inc.
- Age at study initiation: 7 weeks
- Weight at study initiation: 161 - 190 g
- Fasting period before study: Animals were fasted 20 h prior to administration and 4 h after.
- Housing: 2 - 3 animals per cage in aluminium cages
- Diet: solid mouse and rat chow (CRF-1, Oriental Yeast Co., Ltd.); ad libitum (besides fasting period)
- Water: filter-treated Osaka municipal tap water automatic water drinking device; ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 26
- Humidity (%): 40 - 70
- Air changes (per hr): ≥ 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- undiluted solution was administered
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2.11 mL/Kg (2000 mg/kg bw)
- Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 10 and 30 minutes and 1, 2 and 4 hours after administration and once daily thereafter, for 14 days. Individual body weights were determined immediately before administration, 7 and 14 days after administration, and in the event of being discovered dead.
- Necropsy: Performed at the end of the observation period and in the event of being discovered dead.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 300 mg/kg bw: 1/5 females died 2 days after administration;
2000 mg/kg bw: 2 animals and 1 animal were found dead 2 days and 3 days after administration, respectively (cumulative mortality 3/5 females) - Clinical signs:
- other: - 300 mg/kg bw: Excess salivation in 1 animal (10 and 30 min after administration); irregular respiration in 1 animal (from 10 min to 1 h, and 4 h after administration); ataxic gait in 1 animal (from 30 min to 1 h after administration); staining around th
- Gross pathology:
- 300 mg/kg bw:
- animals found dead: Scattered reddened foci in the mucosa of the glandular stomach were noted.
- animals sacrificed at termination: Necropsy and histopathological examination revealed no substance-related findings.
2000 mg/kg bw:
- animals found dead: Retention of gas in the stomach was seen in 1 of the dead animals, and scattered reddened foci in the mucosa of the glandular stomach were noted in all 3 dead animals.
- animals sacrificed at termination: A small thymus was noted in 1 animal, while the other showed no effect attributable to administration of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Oral 4 (H302) according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute oral toxicity study in rats a LD50 value of 300 - 2000 mg/kg bw was determined.
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