L-Arginine, N2-(2,3-dihydroxypropyl)-, monohydrochloride

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 18 March 2020 to 14 July 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, in the dark

Key result

Decomposition:

yes

Decomp. temp.:

ca. 140 °C

Table 2 Thermographic Data

Thermal Event	Interpretation	Temperature (°C)
		Determination 1	Determination 2
Exotherm	Onset of decomposition	140.63	140.33
	Additional decomposition event	~ 230 to 300	~ 230 to 300

Atmospheric pressure: 102 kPa

After heating to 400°C, the samples had lost approximately 69% of their original weight

 

The test item had an erratic baseline from approximately 140°C to 400 °C. This suggested decomposition was occurring throughout this range. The onset of the endotherm at 140 °C could suggest the test had begun to volatilise, but the weight loss was minimal and by approximately 150 °C the baseline indicated that decomposition was occurring. After being heated to 150°C the test item had lost only 4% of its original weight and was a clear sticky solid. When heated to 200°C, the test item became a clear glassy solid and lost 10% of its original weight. At a higher temperature of 300 °C, 28% of the original weight had been lost and became a reddish-brown brittle solid. These demonstrated how the test item was progressively degrading as the temperature increased. By the final test temperature of 400 °C, the test item had erupted out of the crucible and formed a brittle, crusty solid.

From this evidence, it was considered that overall the test item decomposed and that a boiling temperature could not be determined.

Overall result: decomposition from approximately 140°C.

 

Conclusions:

The test item has been determined to decompose from approximately 140 °C (413 K) at 102 kPa. As the test item decomposed, no value for boiling temperature could be determined.

Executive summary:

The test item was determined to have decomposed from approximately 140 °C (413 K) at 102 kPa, by differential scanning calorimetry, designed to be compatible with Method A.2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

As the test item decomposed, no value for boiling temperature could be determined.

Description of key information

Decomposition from 140°C; OECD 103; Fox, J. M. (2020)

Additional information

As the test item decomposed, no value for boiling point could be determined.