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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 952-480-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity in rats: LD50 >5000 mg/kg bw in a test similar to OECD TG 401.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute oral toxicity
A study was performed to assess the acute oral toxicity of the substance to the rat according to a protocol similar to OECD TG 401. A group of four fasted rats (two of each sex) was given a single dose by gavage of the substance, as supplied, at a dose level ranging from 6.4 to 16.0 g/kg bw. All animals were observed for 14 days and necropsied.
Clinical signs observed were ptosis, lethargy, pilo-erection, ataxia, abnormal body carriage, abnormal gait, a decreased respiratory rate, pallor of the extremities and increased salivation. Reduced body weight gains were seen in one male and one female at 6.4 g/kg during the first week of observation and in one female at 10.0 g/kg during the second week of observation, compared to the controls. Body weight gains of the remaining animals were normal throughout the two-week observation period. The acute oral LD50 in rats was determined to be between 6400 and16000 mg/kg bw.
In a supporting study similar to OECD TG 401, the LD50 was assessed to be greater than 5000 mg/kg bw (Moreno, 1982). Clinical signs observed were ptosis, diarrhoea, lethargy, piloerection, ataxia, flaccid muscle tone, chromorhinorrhea, and brown staining of the anogenital area. Gross observations at necropsy were normal for all rats. The substance is not acute orally toxic: LD50 > 5000 mg/kg bw and no acute oral classification is needed.
Acute dermal toxicity
A dermal study is available, demonstrating the LD50 greater than 5000 mg/kg bw (Moreno, 1982). No death occurred at this dose in any of the 10 animals used.
This information does not lead to a different C&L.
Justification for classification or non-classification
The substance does not need to be classified for acute oral (and dermal) toxicity according to EU CLP (EC No. 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.