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Diss Factsheets
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EC number: 210-719-3 | CAS number: 622-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- Not Specified
- No. of animals per sex per dose:
- Not Specified
- Control animals:
- not specified
- Details on study design:
- Not Specified
- Statistics:
- Not Specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 190 mg/kg bw
- Clinical signs:
- BEHAVIORAL: General anesthetic
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Acute Oral LD50 value of 1190 mg/kg bw was determined in a study with limited reliability. In this regard, No details on the study are available. However, The identified value allowed to allocate the substance in the category 4 following GHS Criteria (300 mg/kg bw
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- The substance is only used as active ingredient for cosmetic products. The acute toxicity endpoint (oral route) has been assessed using a weight of evidence approach, avoiding the use of animals for in vivo tests. -In vitro acute toxicity test:: 3T3 NRU cytotoxicity assay oaccording to the OECD guidance document nº 129, the ECVAM OB-ALM nº139 protocol and the EURL ECVAM Recommendation, April 2013
- Qualifier:
- according to guideline
- Guideline:
- other: eries on testing and assessment n°129 , DB-ALM Protocol n°139
- Deviations:
- no
- Principles of method if other than guideline:
- The cytotoxicity assay performed in this study was designed to evaluate the cytoxiic potential of the test item solubilised in the medium culture for 48h towards the fibroblasts cell line BALB/ 3T3 clone A31 (ATCC-CCL-163). After 48h of incubation with different concentrations of the test item with fibroblasts, viability cell is determed by NRU test.
The IC50 value is used in linear regression equation to estimate the oral LD50 value. - GLP compliance:
- yes
- Test type:
- other: in vitro
- Key result
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 432.63 other: mg/Kg
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The test item cannot be classified ad no toxic.
- Executive summary:
The substance is only used as active ingredient for cosmetic products. The acute toxicity endpoint (oral route) has been assessed using a weight of evidence approach, avoiding the use of animals for in vivo tests. -In vitro acute toxicity test:: 3T3 NRU cytotoxicity assay oaccording to the OECD guidance document nº 129, the ECVAM OB-ALM nº139 protocol and the EURL ECVAM Recommendation, April 2013.
Referenceopen allclose all
The test item tested on Balb/3T3 cells showed an IC50 mean value of 1105 mcg/ml, equivalent to an estimated LD50 value of 1432.65 mg/Kg. The test item was tested in two different main tests with 8 different concentrations (10.000; 4651.16; 2163.33; 1006.20; 468.00; 217.67; 101.24; 47.09 mcg/ml). All acceptance criteria were passed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 190 ng/kg bw
Additional information
Justification for classification or non-classification
The substance is only used as active ingredient for cosmetic products. The acute toxicity endpoint (oral route) has been assessed using :
- a weight of evidence approach, avoiding the use of animals for in vivo tests. -In vitro acute toxicity test:: 3T3 NRU cytotoxicity assay oaccording to the OECD guidance document nº 129, the ECVAM OB-ALM nº139 protocol and the EURL ECVAM Recommendation, April 2013
- supporting study (literature)
The identified values allowed to classify the substance in the category 4 following GHS Criteria (300 mg/kg bw<LD50<2000 mg/kg bw)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.