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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD-guideline 402 EEC (February 24, 1987. Adopted) EEC Directive 67/548/EEC, Annex V, B.3.
GLP compliance:
yes
Limit test:
no

Test animals

Species:
other: rabbits

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 0 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 0 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No relevant systemic side-effects were noted. The main
attendant dermal reactions in the T001625 dosed rabbits were
necrosis, a coriaceous skin, thickening and wrinkling of the
skin and crust formation. None of these reactions were
completely reversible after 14 days.
Gross pathology:
Effects on organs:
With exception of the persistent dermal changes no
drug-related systemic macroscopic changes were observed at
autopsy.
Other findings:
Signs of toxicity (local):
All rabbits survived the study.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU