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EC number: 222-001-7 | CAS number: 3312-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-09-13 to 1978-09-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Exposure duration 60 minutes, higher limit dose
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-cyclohexylaminopropylamine
- EC Number:
- 222-001-7
- EC Name:
- 3-cyclohexylaminopropylamine
- Cas Number:
- 3312-60-5
- Molecular formula:
- C9H20N2
- IUPAC Name:
- N1-cyclohexylpropane-1,3-diamine
- Test material form:
- liquid
- Details on test material:
- 3-Cyclohexylaminopropylamine from Performance Chemicals, lot number: 68-219-BC
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley CD rats derived by Charles River
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals purchased from Charles River Breeding Laboratories. Rats were individually housed in metal hanging cages of appropriate size prior to exposure and in plastic crispers with Sanicel bedding during the observation period. All animals were maintained in isolated temperature and humidity controlled animal rooms with filtered air supply and cycled lighting (12 hours of light daily). Purina Laboratory Chow and tested tap water were available ad libitum, except during the exposure time. Rats were acclimated for at least one week prior to initiation of the study.
Rats were selected from stock animals on the basis of body weight and general good health and allocated 5 males and 5 females per dose group. Body weight of young adult rats was between 194 - 238 g.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- >= 0.5 - <= 3 µm
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- The test material was metered from a 3 L reservoir into the continous feed nebulizer chamber of a Devilbiss Ultrasonic Nebulizer (Model 6582)capable of delivering liquid particles in a size range of 0.5 to 3.0 microns. A steam of filtered air wa passed through the nebulizer to produce concentrated aerosol which was introduced into the chamber at the top. The average nominal exposure concentration was calculated by dividing the total weight loss of the test material by the total volume of air used for aerosolination and dilution over the period of operation. The test atmosphere was exhausted at the bottom through an activated charcoal filter to archieved dynamic flow through the chamber.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 60 min
- Remarks on duration:
- After single exposure for 60 minutes the rats were observed for the following 14 days
- Concentrations:
- 7.5 mg/L
- No. of animals per sex per dose:
- 5 groups of 5 males and 5 females (50 animals)
- Control animals:
- yes
- Remarks:
- exposed to air only
- Details on study design:
- Each dose group was placed in a 400 L stainles steal and glass inhalation chamber and caged individually in stainless steal wire mesh cages ( 5 x 5 x 18 cm).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.5 mg/L air
- Exp. duration:
- 60 min
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no effects during the 14 day observation period
- Clinical signs:
- other: no signs of toxicity observed
- Body weight:
- no differences between control and dosed groups and no differences between males and females
- Gross pathology:
- Gross necropsy of all rats after 14 days and examination of the major organs did not reveal any remarkable changes that were attributed to treatment.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this test, the LC50 could not be determined for the test compound. Based on the results, the LC50 would be greater than 7.5 mg/L.
- Executive summary:
After single whole body exposure of young CD rats to the test compound for 60 minutes, no toxicological effects could be seen during the 14 days observation period after the exposure.
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