Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-130-0 | CAS number: 65232-89-5 BP AMOCO IV; E-326 CATALYST; KAT MSA; MSA-KATALYSATORTABLETTEN
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-03-14 to 1991-04-26 (experimental phase)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study with acceptable restrictions, analytical recovery of test substance concentration not sufficient, test medium was turbid with precipitations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Divanadyl pyrophosphate
- EC Number:
- 407-130-0
- EC Name:
- Divanadyl pyrophosphate
- Cas Number:
- 65232-89-5
- Molecular formula:
- (VO)2P2O7
- IUPAC Name:
- (phosphonooxy)phosphonic acid dihydrate vanadium
- Details on test material:
- - Name of test material (as cited in study report): E-326 Catalyst
- Substance type/physical state: grey-green powder
- Lot/batch No.: 326-104
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Duplicate levels were analysed at the start and end of the test; one sample from each pair was analysed immediately and the other was filtered (0.2 micron pore size) before analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test media were prepared individually by adding the total required weights of test material to a series of volumetric flasks containing dilution water (approximately 0.8 litre). Each flask was sonicated for ten minutes before being further diluting to a final volume of twenty litres in the test vessels. Test media were then aerated for approximately one hour before the test was started.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: The batch of rainbow trout used for the definitive test was supplied by Hauxton Fishery Services Limited, Blackborough, Devon. They were reared at West Acre Trout Farm, Kings Lynn, Norfolk, from Danish eggs which hatched January 1991.
- Length at study initiation (length definition, mean, range and SD): 5.2 cm
- Weight at study initiation (mean and range, SD): 1.8 g
- Feeding during test: no
ACCLIMATION
Monitoring water quality during the 14-day holding period immediately preceding the definitive test showed the following (flow through):
- temperatures ranged from 12.0 to 14.7°C
- pH values ranged from 7.5 to 8.2
- dissolved oxygen concentrations (DO) ranged from 84 to 99% air saturation value (ASV)
- water hardness ranged from 240 to 250 mg/l as CaC03.
Each day during the holding period, the fish were fed with proprietary trout pellets (BP Nutrition Ltd., Mainstream Trout Fry 02), an amount equivalent to approximately between 1 and 2% of the total wet-weight of the fish in the holding tank.
Mortality during the seven day period before the definitive test was less than 2.5 %.
The fish were last fed 25 hours before the start of the definitive test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 226-280 mg/L CaCO3
- Test temperature:
- 14.1-14.9 °C
- pH:
- 6.28-8.0
- Dissolved oxygen:
- 83 - 101 %
- Nominal and measured concentrations:
- 0, 100, 180, 320, 560, 1000 mg/L nominal
- Details on test conditions:
- TEST SYSTEM
- Type: open
- Material, size, headspace, fill volume: all-glass aquaria, with a total capacity of 25 litres; the depth of the test dilutions (20 l) was approximately 20.5 cm
- Aeration: yes
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The test organisms were maintained and the study conducted in treated tap water. Treatment involved blending tap water, previously filtered through activated carbon to remove chlorine with tap water, which had been softened and treated by reverse 'osmosis, to achieve hardness in the range 200 - 250 mgl/l as CaC03. This water was delivered to an intermediate tank where it was equilibrated to the test temperature and gently aerated before being supplied to the holding and test areas.
OTHER TEST CONDITIONS
- Adjustment of pH: not during test
- Photoperiod: 16:8 L:D
- Light intensity: no data, dawn and dusk was simulated
EFFECT PARAMETERS MEASURED:
Mortality and behaviour daily
TEST CONCENTRATIONS
- Range finding study: yes
- Test concentrations: 1, 10, 100, 1000 mg/L - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 51.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Any other information on results incl. tables
- Sublethal observations / clinical signs:
E-326 Catalyst affected the pH of the test media which became more acidic with increasing concentration. At all concentrations test media were green, non-homogeneous dispersions with undissolved test material visible in suspension and on the bases of the test vessels; during the test, undissolved test material settled out of suspension.
Concentrations in both filtered and unfiltered samples were lower than nominal values (between 13 and 39% of nominal values), but showed a generally dose-related trend and were maintained over the test period.
The highest concentration at which no mortalities occurred and lowest at which there was 100% mortality after 96 hours were 51.2 and 128 mg/l respectively, based on measured concentrations in unfiltered samples, and 33.2 and 93.5 mg/l based on measured levels in filtered samples. Mortalities were progressive during the test.
At each exposure level except for the highest (nominally 1000 mg/l), some fish exhibited lethargic behaviour, including one at the lowest level which was affected at the end of the test. A no-observed-effect concentration (NOEC) was not therefore obtained but is presumed to be less than 31.4 mg/l based on measured levels in unfiltered test media and less than 20 mg/l based on levels in filtered media.
Table. Approximate median lethal concentrations (LC50s), calculated at intervals during the test using mean measured concentrations in unfiltered and filtered test media:
Time (h)
LC50 (mg/l) un-filtered
LC50 (mg/l) filtered
24
>185
>154
48
120
90
72
83.5
72
96
66.3
51.8
Quoted values are approximate as data did not permit statistfcally valid calculations.
Although measured concentrations were lower than intended, it is considered that the maximum attainable exposure levels were achieved and maintained during the test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.