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EC number: 824-458-3 | CAS number: 1263679-68-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
OECD 471: In vitro bacterial reverse mutation assay: Negative
OECD 473: In vitro chromosome aberration assay using Chinese Hamster lung cells (CHL/IU): Negative
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an OECD 471 study, the potential of HCFO-1233yd(Z) to induce genetic mutations in 5 bacterial strains was evaluated in the absence and presence of metabolic activation (±S9). In both the non-activated and activated assays, the average number of revertants in the test substance group was less than twice that in the corresponding negative control group in all tester strains and the number of revertants did not increase in a dose-related manner. No inhibition of cell growth or precipitation of the test substance was observed in any tested strain. Based on the results observed, the test material was not considered to be mutagenic under the conditions of this bacterial reverse mutation assay.
In a key OECD Guideline 473 study (Safety Research Institute for Chemical Compounds Co., Ltd, 2016), the clastogenic potential of the test material (HCFO-1233yd(Z)) was investigated in vitro using Chinese Hamster lung cells (CHL/IU). The test material was evaluated in three test series: short-term treatment without S9 (-S9 treatment); short-term treatment with S9 (+S9); and continuous 24-hour treatment (24-hr treatment). Based on the results of effects on cell growth, 350, 700, and 1400 µg/mL were selected as the doses.
Incidence of structural and numerical aberrations of chromosomes in the negative control groups of all test series were within the control range based on the historical control data. The incidence of structural aberrations of chromosomes in the positive control group of all test series were within the control range based on the historical control data, and a statistically significant increase was noted compared with the negative control group.
Treatment with the test material resulted in no increase in the incidence of structural or numerical aberrations of chromosomes. Based on the results observed, the test material is was not considered to be clastogenic to cultured mammalian cells under the conditions of this in vitro chromosome aberration test.
In a key OECD guideline 476 study, the test item did not induce any toxicologically significant increases in the mutant frequency at any of the concentration levels in the main test using a dose range that included the 10 mM limit dose level, in either the absence or presence of metabolic activation.Therefore, the test item was shown to be non-mutagenic to V79 cells at the HPRT locus under the conditions of the test.
Justification for classification or non-classification
The available in vitro data indicate that classification for genotoxicity is not warranted.
HCFO-1233yd(Z) is not classified according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 or UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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