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EC number: 206-585-0 | CAS number: 355-42-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- November 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Deviations:
- not applicable
- Remarks:
- QSAR
- Principles of method if other than guideline:
- The chronic toxicity to fish was determined using a validated QSAR for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (3). The QSAR is based on validated data for a training set of 26 chemicals derived from 14 to 32-day test on fish, for which the concentrations of the test item had been determined by chemical analyses over the test period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetradecafluorohexane
- EC Number:
- 206-585-0
- EC Name:
- Tetradecafluorohexane
- Cas Number:
- 355-42-0
- Molecular formula:
- C6F14
- IUPAC Name:
- tetradecafluorohexane
- Test material form:
- liquid
Constituent 1
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Results from the following species were used in the regression:
Danio rerio, Pimephales promelas, Oryzias latipes, Leuciscus idus, Jordanella floridae, Cyprinus carpio
Study design
- Test type:
- flow-through
- Water media type:
- not specified
- Total exposure duration:
- 28 d
- Remarks on exposure duration:
- Only results from a test duration of 14* to 32 days were included. The median study duration was 28 days.
Test conditions
- Test temperature:
- The temperatures varied from approximately 21 to 27 °C depending on the fish species used to construct the algorithm.
- pH:
- Test results were taken from studies with measured pHs between 6.0 - 8.5
Results and discussion
Effect concentrations
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 0.11 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- ChV (chronic value, QSAR)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item falls within the applicability domain of the model and can therefore be considered a reliably prediction for chronic toxicity (28d-NOEC) to fish. Therefore, this endpoint value can be considered valid for use in risk
assessment and classification and labelling.
The 28d-NOEC of the test item to fish was predicted as 0.11 mg/L.
95% confidence interval (α = 0.05): 0.087 – 0.14 mg/L.
The QPRF can be found as a separate document (8).
The QMRF can be found as a separate document (9). - Executive summary:
Introduction.
A QSAR model model was used to calculate the chronic toxicity to fish of the test item 1,1,1,2,2,3,3,4,4,5,5,6,6,6-TETRADECAFLUOROHEXANE. This QSAR model has been validated to be compliant with the OECD recommendations for QSAR modeling (OECD, 2004) (1) and predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following Guideline for Testing of Chemicals No. 210, "Fish, Early-life Stage Toxicity Test" (2). The criterion predicted was the NOEC (No Observed Effect Concentration), a tested concentration which is observed to cause no effect on growth or reproducibility within a period of 28 days.
Methods.
The chronic toxicity to fish was determined using a validated QSAR for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (3). The QSAR is based on validated data for a training set of 26 chemicals derived from 14 to 32-day test on fish, for which the concentrations of the test item had been determined
by chemical analyses over the test period.
Results.
The result below is the chronic toxicity value anticipated during a 28-day NOEC study on fish. The 28-day
NOEC is calculated as follows:
Time (d)
NOEC (mg test item.L-1)
95% confidence limits (mg test item.L-1)
28
0.11
0.087 – 0.14
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