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Diss Factsheets
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EC number: 253-379-1 | CAS number: 37172-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 is >5000 mg/kg bw
Dermal LD50 is >5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- - Description: Clear liquid
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300g
- Fasting period before study: 18 hours
- Housing: 5/cage in wire mesh cages in a temperature controlled room
- Diet: Fresh Purina Rat Chow, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: at least one week - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: mortality and signs of toxicity at 3-4 hours after dosing and daily for 14 days. All rats were examined for gross pathology. - Key result
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: Lethargy was observed in 2 animals on day 0. Chromorhinorrhea was noted in 1 animal on day 9.
- Gross pathology:
- One animal had a dark liver and a pale kidney. One animal had red and yellow areas on intestines and a dark kidney.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- One Klimisch 2 study available. Performed similar to guideline.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- One Klimisch 2 study available. Performed similar to guideline.
Additional information
Acute oral toxicity:
In an acute oral toxicity study performed similar to OECD 401 (except body weight determination), the test substance was administered via oral gavage to ten male Wistar rats. The concentration administered was 5000 mg/kg bw and the animals were observed for 14 days. No mortality was observed. Lethargy was observed in 2 animals on day 0. Chromorhinorrhea was noted in 1 animal on day 9. One animal had a dark liver and a pale kidney. One animal had red and yellow areas on intestines and a dark kidney. The LD50 was determined to be >5000 mg/kg bw.
Acute dermal toxicity:
In an acute dermal toxicity study performed similar to OECD 402, the test substance was administered dermally under occlusive conditions for 24 hours to ten New Zealand White rabbits. The concentration applied was 5000 mg/kg bw and the animals were observed for 14 days. In half, abrasions were made longitudinally every 2-3 cm over the exposed area. The abrasions were sufficiently deep to penetrate the stratum corneum but not deep enough to produce bleeding. Two animals died. Adverse effect observed among the surviving animals included diarrhea and mucous in the stool. Upon necropsy, dark liver, brown anogenital exudate, bloated intestines was observed in the survived animals. More severe effects were observed in the animals who died. The LD50 was determined to be >5000 mg/kg bw.
Justification for classification or non-classification
The test substance does not have to be classified for acute oral or dermal toxicity according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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