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EC number: 429-320-2 | CAS number: 24748-23-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
There is no specific requirement to generate TK information in REACH. (R.7.12.1). There are no adequate studies that completely address toxicokinetics (i.e. absorption, metabolism, distribution and elimination). Physical-chemical properties were used to estimate absorption via oral, dermal and inhalation exposure.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 20
- Absorption rate - inhalation (%):
- 100
Additional information
Toxicokinetic Summary
1,2,4,5,7,8-Hexoxonane, 3,6,9-triethyl-3,6,9-trimethyl- CAS# 24748-23-0 is a cyclic peroxy ketone.
MW |
Water Solubility |
Log P |
Vapor Pressure |
Surface Tension |
Systemic Toxicity |
264 |
13.1 mg/L (slightly soluble) |
4.84 |
4.1 Pa (0.0041 KPa) |
Log10 Koc 3.16 |
Yes 90-day oral |
No studies are available on the toxicokinetics, metabolism and distribution of this substance. The pure peroxide is not commercially available.
Oral Absorption
There is no information on the oral absorption of this peroxide. While the water solubility would not favor absorption, repeat dose studies indicate systemic effects (liver, kidney and blood).
In a hydrolysis study, OECD 111, under the physiologically relevant conditions of pH 1.2, 37.0 ± 0.5 °C, the mean half-life of the test item was determined to be 0.23 hours (14 minutes), with a rate constant of 8.41 x 10-4s-1.
Dermal Absorption
Per ECHA Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance for dermal absorption:
MW: <100 favors absorption; > 500 does not
WS: 1-100 mg/L absorption is low to moderate
Log P: 1-4 favors absorption, > 4 penetration is limited by rate of transfer between stratum corneum and epidermis
VP: vapors with < 100 Pa are likely to be well absorbed and the amount absorbed dermally may be morethan 10% of the amount that would be absorbed by inhalation.
Based on the above guidance and physical-chemical properties, dermal absorption of the registered substance is estimated to be ~20% of oral absorption.
Inhalation Absorption
Per ECHA Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance for inhalation absorption:
VP: substances with VPs > 24 KPa are highly volatile; < 0.5 KPA have low volatility
Log P: 1-4 favors absorption, > 4 favors micellular solubilization if poor WS (1 mg/L or less)
WS: low WS enhance penetration to lower respiratory tract.
Based on the above guidance and physical-chemical properties, it is difficult to estimate the absorption via inhalation exposure of the registered substance. Therefore due to lack of information, for route to route extrapolation, a worse case will be assumed i.e. absorption via inhalation is twice that of oral absorption (Guidance on information requirements and chemical safety assessment, Chapter R 8.4).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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