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Diss Factsheets
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EC number: 701-287-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Secondary citations (Klimisch 4) for the component barium chromate (15% of the substance) and/or CrVI:
- Gene mutation: positive in one bacterial strain TA 100 but only when solubilized in NTA (negative unsolubilized or solubilized by NaOH)*
- Increased frequency of sister chromatid exchange in CHO cells. This effect was increased by addition of NTA, however cells were able to absorp the compound by endocytosis without this solvent.*
- Increase in morphological transformation in cultured Syrian hamster embryo cells.**
- Elevated levels of sister chromatid exchange were observed in workers exposed to chromium[VI] compounds in electroplating factories in four out of six studies. Chromosomal aberrations were found in all three studies of exposed workers; an increase frequency of aneuploidy was reported in one study.***
*: source: Cross HJ, Faux SP, Sadhra S et al. Criteria Document for Hexavalent Chromium. International Chromium Development Association. April 1997.
**: source: review: Kerckaert GA, Brauninger R, LeBoeuf RA et al. Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays. Environ Health Perspect. 1996 October; 104(Suppl 5): 1075–1084
***: peer-reviewed source: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans - Volume 49 - Chromium, Nickel and Welding. Last updated: 5 November 1997
Published data also evidenced clastogenic potential and mammalian gene mutation (mainly due to deletion) with barium chromate.
No data on the full registered substance.
Therefore, as human data are available on mutagenicity (but these data only referred to a substance closed to one consituant (15%) of the registered substance), it was considered that the registered substance is classified Muta Cat 3 according to criteria of Directive (EEC) N° 67/548/CEE. Consequently the registered substance is classified M2 under Regulation (EC) 1272/2008.
Short description of key information:
Data on the component barium chromate (15% of the registered substance, only CrVI source) show that it induces gene mutation, aneuploidy and chromosome aberration.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
Barium chromate, 15% of the registered substance, has a genotoxic potential when appropriately solubilized, according to secondary literature and also to non-standard (see RSS) clastogenicity and mammalian gene mutation assays.
Therefore the registered substance is considered as a mutagen. However, in the absence of data on in vivo mutagenic potential, no classification is possible. An in vivo test is therefore proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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