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EC number: 255-350-9 | CAS number: 41395-83-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- No purity of test substance reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 1981
- Deviations:
- not applicable
- Qualifier:
- according to guideline
- Guideline:
- other: Journal Officiel de la Republique Francaise 1971/1973
- Deviations:
- not specified
- Principles of method if other than guideline:
- Study was conducted prior to adoption of any OECD guidelines.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylene dinonanoate
- EC Number:
- 255-350-9
- EC Name:
- Propylene dinonanoate
- Cas Number:
- 41395-83-9
- Molecular formula:
- C21H40O4
- IUPAC Name:
- propylene dinonanoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: about 2.5 kg at study start
Animals were vaccinated against myxomatosis and selected only if normal eye condition; any rabbits with ocular lesions were excluded.
- Housing: Individual cages (600x540x315 mm) or restraining devices
- Diet: 200 g commercial rabbit feed per day in the form of granules
- Water: ad libitum
- Climate: air conditioned
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: yes, each animals untreated right eye served as control
- Amount / concentration applied:
- 0.1 mL of undiluted test substance as supplied by sponsor was instilled to the left eye.
- Duration of treatment / exposure:
- Single instillation
- Observation period (in vivo):
- Readings were after 1, 24, 48, 72 hours, and 4 and 7 days after administration
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
No rinsing of eyes was done.
SCORING SYSTEM:
Chemosis: Scores 0-4
Conjunctival enanthema: Scores 0-3
Iris: Scores 0-2
Corneal opacity: Scores 0-4
TOOL USED TO ASSESS SCORE: ophtalmoscope
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #3, #6
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: #4, #5
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3, #4, 5#, #6
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- iris score
- Basis:
- animal #5
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3, #4, #6
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1, #3, #5, #6
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #2, #4
- Remarks:
- individual mean over
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Other effects:
- No mortality occurred during this study.
Any other information on results incl. tables
|
|
Animal # |
|
|
|
|
|
|
Reading time [hour] |
#1 |
#2 |
#3 |
#4 |
#5 |
#6 |
Chemosis |
24 |
0 |
1 |
0 |
0 |
0 |
1 |
Chemosis |
48 |
1 |
1 |
1 |
0 |
0 |
0 |
Chemosis |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Individual mean |
0.33 |
0.67 |
0.33 |
0.0 |
0.0 |
0.33 |
Redness conjunctivae |
24 |
1 |
0 |
1 |
0 |
1 |
1 |
Redness conjunctivae |
48 |
0 |
0 |
0 |
0 |
0 |
0 |
Redness conjunctivae |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Individual mean |
0.33 |
0.0 |
0.33 |
0.0 |
0.33 |
0.33 |
Iris |
24 |
0 |
0 |
0 |
0 |
1 |
0 |
Iris |
48 |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Individual mean |
0.0 |
0.0 |
0.0 |
0.0 |
0.33 |
0.0 |
Cornea opacity |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
Cornea opacity |
48 |
0 |
0 |
0 |
0 |
0 |
0 |
Cornea opacity |
72 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Individual mean |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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