Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity of the test item was based on the data on acute oral toxicity for tetradecanoic acid, used for the read-across since the test item is a reaction mass of tetradecanoic anhydride and tetradecanoic acid.
For tetradecanoic acid, data on acute oral toxicity are published and LD50 Rat oral >10000 mg/kg is reported, which classify the substance as not toxic via oral route. Therefore also the test item is considered not toxic via oral route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Guideline:
- other: Information not available from the abstract
- GLP compliance:
- not specified
- Remarks:
- Information not available from the abstract
- Species:
- rat
- Route of administration:
- oral: unspecified
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the test result (LD50 Rat oral >10000 mg/kg), tetradecanoic acid is not considered toxic via oral route.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- Since the test item is a reaction mass of tetradecanoic anhydride and tetradecanoic acid, tetradecanoic acid was used for the read-across.
- Reason / purpose for cross-reference:
- read-across source
- Guideline:
- other: Information not available from the abstract
- GLP compliance:
- not specified
- Remarks:
- Information not available from the abstract
- Species:
- rat
- Route of administration:
- oral: unspecified
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the test result (LD50 Rat oral >10000 mg/kg), tetradecanoic acid is not considered toxic via oral route.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
