Registration Dossier
Registration Dossier
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EC number: 919-697-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The substance is slightly irritating to skin and eyes of rabbits. In vitro tests using an artificial 3D-Skin model revealed neither corrosive nor irritating properties of the test substance.
tests using an artificial 3D-Skin model revealed neither corrosive (OECD TG 431) nor irritating (EU Method B.46) properties of the test substance in vitro (Wingenroth, 2011a,b).
tests using an artificial 3D-Skin model revealed neither corrosive (OECD TG 431) nor irritating (EU Method B.46) properties of the test substance in vitro (Wingenroth, 2011a,b).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The substance was slightly irritating to the skin of rabbits according to OECD TG 404 (Gmelin, 2010a). All signs were fully reversible within one week. No relevant systemic intolerance reactions were observed. In addition, tests using an artificial 3D-Skin model revealed neither corrosive (OECD TG 431) nor irritating (EU Method B.46) properties of the test substance in vitro (Wingenroth, 2011a,b).
According to GHS classification criteria the substance is not an irritant to the skin.
Eye irritation
The substance was slightly irritating to the eyes of rabbits according to OECD TG 405 (Gmelin, 2010b). In all animals redness of conjunctivae were fully reversible within 3 days. No systemic intolerance reactions were observed. In addition, the test substance was identified as "non-irritant" to the chorioallantoic membrane (irritation score (IS) = 0) in the in vitro HET-CAM test according to a protocol recommended by ICCVAM, Nov. 2006 (Wingenroth, 2011c).
According to classification criteria the substance is not an irritant to the eyes.
Justification for selection of skin irritation / corrosion
endpoint:
Only one key study available
Justification for selection of eye irritation endpoint:
Only one key study available
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the study results a classification according to Regulation (EC) No.1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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