Registration Dossier
Registration Dossier
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EC number: 444-340-1 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
MV31 K salt has a hydrolysis half life of > 1 year under environmental conditions (25°C), it is considered hydrolytically stable.
Key value for chemical safety assessment
Additional information
Hydrolysis of MV31 K salt test solutions was performed in 2001 according to the OECD 111: hydrolysis as a Function of pH. Hydrolysis study was conducted in pH 4,7,and 9 buffer and at 50 °C for 5 days. After 5 days, the samples were cooled, and the unhydrolyzed test substance (parent compound) was analyzed using HPLC immediately. The initial concentration was calculated by the sample weight. Hydrolysis rate were determined by % decomposition of the test material. The % decomposition of MV31 K salt at pH 4, pH 7 and pH 9 ranged from -2.87 to 0.66% after 5 days at 50°C, the hydrolysis half- life is reported as > 1 year at environmental temperature of 25 °C. MV31 K salt is considered hydrolytically stable. This is a guideline study conducted under GLP. Therefore, it is considered to be reliable with acceptable restriction and a key study.
Another study was also conducted in 2001 to determine the stability of MV31 K salt in water. MV31 K saltwere prepared at two concentration levels in deionized water and stored for 0 hour, 6 hours and 15 days at room temperature. Concentrations ofMV31 K saltwere analyzed by HPLC. The overall % recoveries of MV31 K salt ranged from 91 to 105% after stored at room temperature (20 °C) for 0h, 6h and 15 days. MV31 K salt is considered hydrolytically stable. This study meets generally accepted scientific principles, it is acceptable with restrictions and a supporting study.
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