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EC number: 281-468-5 | CAS number: 83950-14-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Rats (5/sex/dose) received a single dose of the substance by gavage ( 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg). Mortality (within 4 hours after dosing) was 0, 0, 3, 4 ,9 and 10 at 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg. During the 14 day observation period diarrhea, nausea, sedation and convulsions were observed in surviving animals. Necropsy of decedents was not possible due to orange discoloration of the organs. In survivors no abnormalities were recorded. The LD50 (as assessed by the author of the report) is 1700 mg/kg bw. No correction for purity was made as the composition of the tested substance is similar to that of the substance subject to registration (Bayer 1981)
In an acute dermal toxicity study (limit test) the LD50 of the substance is > 2000 mg/kg bw (Eurofins 2017). No signs of toxicity were observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October-November 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Borchen Germany
- Strain: Wistar TNO/W
- Age at study initiation: males 9 weeks. females 14 weeks
- Weight at study initiation: males 157-185 g, females 151-176 g
- Fasting period before study: yes 16 hours pre-dosing and 4 hours post-dosing
- Housing: 5/sex in Macrolon type III cages
- Diet: Altromin R3 1324 (Altromin GmbH Lage, Germany) ad libitum
- Water: tap water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1.5 °C
- Humidity (%): 60 °C 5 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: clinical signs and mortality twice daily
- Body weight: on day 0, 7 and 14
- Necropsy: on all animals - Statistics:
- probit analyses
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.56 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.38 - <= 1.8
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 700 mg/kg bw
- Based on:
- test mat.
- Mortality:
- males: 0, 0, 1, 1 ,4 and 5 at 0.31, 1.0, 1.25, 1.6 2.5 and 5.0 mL/kg
females: 0, 0, 2, 3, 5 and 5 at 0.31, 1.0, 1.25, 1.6 2.5 and 5.0 mL/kg
Mortality was within 4 hours after dosing - Clinical signs:
- at 1.0 mg/L: nausea in one male and one female
at 1.25 mg/L: diarrhea, nausea and sedation in all animals
at 1.6 and above: diarrhea, nausea, sedation and convulsions in all animals - Body weight:
- no data
- Gross pathology:
- In decedents: orange discoloration prevented examination
in survivors: no findings - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 in rats is 1700 mg/kg bw
- Executive summary:
Rats (5/sex/dose) received a single dose of the substance by gavage ( 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg). Mortality (within 4 hours after dosing) was 0, 0, 3, 4 ,9 and 10 at 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg. During the 14 day observation period diarrhea, nausea, sedation and convulsions were observed in surviving animals. Necropsy of decedents was not possible due to orange discoloration of the organs. In survivors no abnormalities were recorded. The LD50 (as assessed by the author of the report) is 1700 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 700 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 September 2017 to 26 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, 97633 Sulzfeld, Germany
- Strain: WISTAR rats Crl: WI(Han)
- Females (if applicable) nulliparous and non-pregnant:yes
- Age at study initiation: males 9-10 weeks; females 12-13 weeks
- Weight at study initiation: Males: 235g - 244g; Females 205g - 227g
- Fasting period before study: NA
- Housing: individually in in IVC cages, type III H, polysulphone cages on Altromin saw fibre bedding
- Diet: Altromin 1324 maintenance diet for rats and mice ad libitum
- Water: tap water, sulphur acidified to a pH value of approximately 2.8 ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 55 ± 10 %
- Air changes (per hr): 10/hour
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 10% of the body surface
- % coverage: 10% of the body surface
- Type of wrap if used: gauze-dressing and non-irritating tape and was fixed with an additional dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes with aqua ad injectionem
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Clinical signs and irritation (Draize): once within 30 min after dosing, several times upto 4 hours after dosing, daily thereafter
- Body weight: on day 1, 8 and 15
- Necropsy of survivors performed: yes macroscopic examination
- Statistics:
- NA
- Key result
- Sex:
- male/female
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: irritation was observed
- Mortality:
- none
- Clinical signs:
- no systemic effects, red discoloration of the skin in all animals
- Body weight:
- within normal limits
- Gross pathology:
- no findings
- Other findings:
- A crust was observed in 3 of 5 male and 1 of 5 female animals.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the substance is > 2000 mg/kg bw
- Executive summary:
LD50: > 2000 mg/kg bw
Species/strain: WISTAR Crl: WI(Han) rats
Vehicle (moistening): no vehicle used
Number of animals: 5 male and 5 female
Duration of exposure: 24 hours
Method: OECD 402, EC 440/2008, Method B.3
Table1: Results
Sex
Dose
(mg/kg bw)Number
of AnimalsNumber
of Intercurrent Deathsmale
2000
5
0
female
2000
5
0
bw = body weight
Signs of systemic toxicity related to dose level used, time of onset and duration:
No treatment-related effects were observed.
Effect on organs (related to dose level):
No treatment-related effects were observed.
Signs of irritation:
No erythema or oedema was observed. A crust was observed in 3 of 5 male and 1 of 5 female animals.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Based on the available information, the substance needs to be classified as H302: Harmful if swallowed (acute tox cat 4) according to EC Regulation No 1272/2008 (CLP). No classification for acute dermal toxicity is considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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