Reaction mass of Copper,di-µ-iodotris[triphenylphosphine]di- and iodobis(triphenylphosphino)copper

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Considering the structural similarities of the substances "Reaction mass of Copper,di-µ-iodotris[triphenylphosphine]di- and iodobis(triphenylphosphino)copper" and "Iodotris(triphenylphosphino)copper" and the almost identical physical and chemical properties, especially partition coefficients and water solubilites, it can be expected that these substances will show quite similar behaviour with respect to short-term aquatic toxicity to fish, too.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: OECD 203

GLP compliance:

yes

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 219001
- Expiration date of the lot/batch: January 01, 2004


STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: dry, room temperature, closed container

Analytical monitoring:

no

Details on test solutions:

The nominal concentration of the test group was 100 mg/l. 400 mg test item and 4 l
reconstituted water were mixed and stirred for about 24 hours. The test item preparation with
the solid particles of the insoluble test item was used for the test.

Test organisms (species):

other: Brachydanio rerio (Zebrabärbling)

Details on test organisms:

Source: Labor- und Zierfischzuchtbetrieb Gunter Rosenhainer, D-06766 Thalheim

Test type:

semi-static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Hardness:

224 mg CaCO3/L

Test temperature:

21.0 - 21.2°C

pH:

7.6 - 7.9

Dissolved oxygen:

>96%

Nominal and measured concentrations:

0 mg/l; 100 mg/l

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

72 h

Dose descriptor:

LC50

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 0.6 mg/L

Nominal / measured:

estimated

Conc. based on:

other: Solubility limit

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Sublethal observations / clinical signs:

Mortality after 96 hours exposure

Number	Designation	Nominal concentration [mg/l]	Mortality [%]
1	Control	0	0
2	Test Item	100	0

Validity criteria fulfilled:

yes

Conclusions:

In the present study the test item in a nominal concentration of 100 mg/l did not cause any
mortality of fish. The LC50 (96 hours) fish of the test item is greater than 100 mg/l (nominal
concentration). The test item is not acute toxic to fish.

Executive summary:

In the present study the test item in a nominal concentration of 100 mg/l did not cause any

mortality of fish. The LC50 (96 hours) fish of the test item is greater than 100 mg/l (nominal

concentration). The test item is not acute toxic to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

100 mg/L

Additional information

LC50 value is above the solubility limit.