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EC number: 258-548-3 | CAS number: 53423-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 August 2018 to 09 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2130 (Hydrolysis as a Function of pH and Temperature)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Reference Identification: Sodium 2,4,5-trichlorobenzenesulphonate
CAS#: 53423-65-7
EC# 258-548-3
Common Name: STB-FR
Product Sample: Sodium Trichlorobenzene Sulfonate; (STB-FR) Lot: 1804-11 Approx. 300g
Date and Quantity Received: 05 Jun 18; 314.3 g (GW)
Physical Description: Solid white powder
Storage Conditions: Room temperature - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Measurements of the test item in the buffered solutions were at the beginning of the experiment on Day 1 and at the end of the experiment on Day 5.
- Buffers:
- Stock Solutions for Buffer Preparations:
To make the stock solutions for pH 4 buffer, 0.286 mL of glacial acetic acid and 0.4102 g of sodium acetate was brought to 50 mL volume in separate flasks with HPLC water. To make the stock solution for the pH 7 buffer, 0.6800 g of potassium phosphate was brought to 50 mL with HPLC water. To make the stock solutions for the pH 9 buffer, 0.3091 g of boric acid and 0.3728 g potassium chloride were placed together and brought to 50 mL volume with HPLC water.
Buffer Preparations:
The pH 4.0 buffer solution was prepared by mixing 18 mL of the sodium acetate solution with 82 mL of acetic acid solution. The pH 7.0 buffer solution was prepared by mixing 29.63 mL of sodium hydroxide with 50 mL of potassium phosphate solution and bringing it to 100 mL with HPLC water. The pH 9.0 buffer solution was prepared by mixing 21.3 mL of sodium hydroxide and 50 mL of boric acid and bringing it to 100 mL with HPLC water.
Buffers were sterilized by autoclave immediately after preparation and the pH verified against standardization solutions. The pH was determined using a Fisher Scientific Accumet AB15 pH meter using an ATC Epoxy Body Liquid-filled Combination Electrode with Ag/AgCl Reference for all pH measurements pursuant to the study. - Details on test conditions:
- Sample aliquots were added to three buffer solutions and analyzed by high performance liquid chromatography to determine concentration of the solution at pH 4, pH 7 and pH 9 for a baseline analysis. Samples were then stored at 50°C for five days and the analysis was repeated on Day 5.
- Duration:
- 5 d
- pH:
- 3.9
- Temp.:
- 50 °C
- Initial conc. measured:
- 3 135.16 mg/L
- Duration:
- 5 d
- pH:
- 7.06
- Temp.:
- 50 °C
- Initial conc. measured:
- 3 089.92 mg/L
- Duration:
- 5 d
- pH:
- 8.98
- Temp.:
- 50 °C
- Initial conc. measured:
- 3 063.45 mg/L
- Number of replicates:
- 3
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- There was less than 10% degradation at pH 4, pH 7, and pH 9 after 5 days.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- The substance did not hydrolyze at pH 4, pH 7, or pH 9 after 5 days.
- % Recovery:
- 99.07
- St. dev.:
- 3.84
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 99.02
- St. dev.:
- 3.84
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 96.63
- St. dev.:
- 3.84
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 8 909 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 8 460 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 2 425 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance does not hydrolyze at pH 4, pH 7, or pH 9 at 50 deg C after 5 days.
- Executive summary:
In a GLP OECD 111 guideline study to assess hydrolysis as a function of pH, the test substance did not degrade by more than 10% after 5 days at pH 4, pH 7, or pH 9 and 50 deg C and can therefore be regarded as hydrolytically stable and no further testing is needed. Estimated half-lives were 2425 hours at pH 9, 8460 hours at pH 7, and 8909 hours at pH 4.
Reference
Variance from Day 0 to Day 5
pH |
Day0 (mg/L) |
Day5 (mg/L) |
Change (mg/L) |
Variance (%) |
pH4 |
3135.16 |
3106.02 |
-29.14 |
-0.93 |
pH7 |
3089.92 |
3059.69 |
-30.23 |
-0.98 |
pH9 |
3063.45 |
2960.17 |
-103.28 |
-3.37 |
Description of key information
In a GLP OECD 111 guideline study to assess hydrolysis as a function of pH, the test substance did not degrade by more than 10% after 5 days at pH 4, pH 7, or pH 9 and 50 deg C and can therefore be regarded as hydrolytically stable and no further testing is needed. Estimated half-lives were 2425 hours at pH 9, 8460 hours at pH 7, and 8909 hours at pH 4.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 2 425 h
- at the temperature of:
- 50 °C
Additional information
Estimated half-lives were 2425 hours at pH 9, 8460 hours at pH 7, and 8909 hours at pH 4.
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