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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 December 2017 - 30 May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Test no.:
#3
Temp.:
25 °C
Vapour pressure:
0 Pa
Test no.:
#4
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: Limit value reported as overall vapour pressure value for test item

For runs 1 and 2, there were initial high weight losses at lower temperatures. This was indicative of degassing of the sample. Only the data from runs 3 and 4 have therefore been reported. The final results were considered to be below the threshold of accurate sensitivity of the instrument. In addition, the lower range of the effusion method according to OECD Method 104 is 1 x 10-10 Pa. Based on a consideration of each of the regressions used to extrapolate the vapour pressure, a limit value has been estimated as less than 1 x 10-7Pa at 25°C. This represents the highest vapour pressure that could be calculated from the data set.

Table 1: Summary of vapour pressure results

 Parameter  Run 3  Run 4
 Correlation (R2)  0.9084  0.9763
 Slope  -9320  -8442
 Intercept  17.48  14.95

 log10PT at 25 °C

 -14

 -13

 PT (Pa) at 25 °C

 1.6 x 10 -14

 4.3 x 10 -14

Table 2: Vapour Pressure Measurements (Run 3)

Temperature (°C)

  Evaporation rate, VT, (g/minute)  log10VT  log10PT
 218.37  0.00000001910  -5.234  -1.590
 223.37  0.00000009432  -4.540  -0.8480
 228.34  0.00000006636  -4.693  -1.011
 233.33  0.0000001074  -4.484  -0.7876
 238.33  0.0000001103  -4.472  -0.7752
 243.33  0.0000001387  -4.373  -0.6688

The VT for the measurement at 223.37°C was anomalously high and was therefore excluded from the calculations as an outlier.

Table 3: Vapour Pressure Measurements (Run 4)

Temperature (°C)

  Evaporation rate, VT, (g/minute)  log10VT  log10PT
 253.36  0.00000005379  -4.784  -1.109
 258.35  0.00000008210  -4.600  -0.9125
 263.34  0.0000001070  -4.485  -0.7894
 268.34  0.0000001642  -4.299  -0.5904
 273.33  0.0000001836  -4.251  -0.5385
Conclusions:
The vapour pressure of the test item was determined to be < 1 x 10-07 Pa at 25°C.
Executive summary:

The vapour pressure of the test item was determined in a study following OECD 104 and EC Method A.4 guidelines, using the effusion method. The vapour pressure of the test item was determined to be < 1 x 10-7 Pa at 25°C.

 

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.

Description of key information

The vapour pressure of the test item was determined to be <1 x 10-7 Pa at 25°C.

Key value for chemical safety assessment

Additional information

The vapour pressure of the test item was determined in a study following OECD 104 and EC Method A.4 guidelines, by the effusion method using isothermal thermogravimetry analysis.

 

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.