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EC number: 246-332-1 | CAS number: 24593-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-08-10 to 2018-08-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 938 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- >= 1 - <= 3 d
- Temp.:
- 20 °C
- pH:
- >= 5.37 - <= 5.8
- Remarks on result:
- other: S.D.: ± 51 mg test item/L
- Remarks:
- Calculated on a mean of dissolved cerium concentration of 216 ± 12 mg/L and a cerium content of 23.0 %.
- Water solubility:
- 216 mg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Ce
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- >= 1 - <= 3 d
- Temp.:
- 20 °C
- pH:
- >= 5.37 - <= 5.8
- Remarks on result:
- other: S.D.: ± 12 mg Ce/L
- Details on results:
- - Mean temperature: 20.1 ± 0.2 °C
- pH values: solutions containing the test item: 5.4 – 5.8, method blanks: 7.2 - 8.5.
- Oxygen concentration: No oxygen was measurable
- Turbidity: The turbidity in samples from test was always 0.02 NTU indicating that filtered solutions did not contain any undissolved material immediately after filtering.
Analytical measurements
The calculated variations / changes between sampling points were less than 15 % for the day 1, 2 and 3. Thus, the validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled. Based on the dissolved measured cerium concentration the content of dissolved test item is calculated. Cerium concentrations in method blanks were measured to be below the LOD (LOD = 0.003 μg/L Ce). - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of ~ 4 g/L test substance for three replicates), a solubility equilibrium was reached. The mean of dissolved cerium concentrations (< 0.22 μm) measured on day 1, 2 and 3 at 20.1 ± 0.3 °C is 216 ± 12 mg/L via ICP-MS, corresponding to a water solubility of 938 ± 51 mg /L test item, based on a cerium content of 23.0 %.
Reference
ICP-MS measurement series with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
Calibration [μg/L] – lowest and highest calibration point |
Chosen wavelength [nm] |
LOD [μg/L] |
LOQ [μg/L] |
correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
August 16, 2018; measurement of test samples and method blanks (day 1, 2, 3) |
||||||
1.0 – 500 (total of 11 calibration points, 11 used + blank) | 142Ce in helium mode |
Ce: 0.003 | Ce: 0.008 | Ce: 0.9999 | Ce: 21 | Ce: 100 |
Recovery/ validation data of cerium - measurement series on August 16, 2018
Element Ce | Recovery [%] | SD [%] | n (total) | n (valid) |
Roth + Ce 40 μg/L | 94.4 | 1.7 | 6 |
6 |
Roth + Ce 400 μg/L |
101 |
1.6 |
6 |
6 |
Recalibration standard 100 μg/L |
94.1 |
1.3 |
6 |
6 |
Fortification of measurement series on August 16, 2018
Sample |
element |
measured concentration [μg/L] |
calculated level after addition [μg/L] |
recovery [μg/L] / [%] |
Vessel 2 sample b 1d (18AB1451, dilution 2000-fold) – 1 mL sample, 4 mL 200 μg/L standard |
Ce |
113 |
183 |
184 / 101 |
Vessel 1 sample b 2d (18AB1465, dilution 2000-fold) – 1 mL sample, 4 mL 300 μg/L standard |
Ce |
107 |
261 |
259 / 99.2 |
Vessel 2 sample b 3d (18AB1463 dilution 2000-fold) – 1 mL sample, 4 mL 400 μg/L standard |
Ce |
105 |
341 |
336 / 98.5 |
Measured dissolved Ce concentrations of solutions containing the test item (1d, 2d, 3d: triplicate vessels; a, b: duplicate samples).
Sample |
LOD [µg/L] |
LOQ [µg/L] |
Measured Ce conc. [µg/L] |
Ce conc. [mg/L] (dilution factor: 2000) |
Mean Ce conc. per vessel ± SD [mg/L] |
Mean Ce conc. all vessels ± SD [mg/L] |
Variation / change between samplings [%] |
1a day 1 |
0.003 |
0.008 |
113 |
225 |
228 ± 4 |
223 ± 5 |
|
1b day 1 |
116 |
231 |
|||||
2a day 1 |
106 |
213 |
219 ± 9 |
||||
2b day 1 |
113 |
226 |
|||||
3a day 1 |
110 |
220 |
221 ± 1 |
||||
3b day 1 |
111 |
222 |
|||||
1a day 2 |
0.003 |
0.008 |
102 |
204 |
209 ± 7 |
214 ± 12 |
3.9 |
1b day 2 |
107 |
214 |
|||||
2a day 2 |
108 |
216 |
228 ± 7 |
||||
2b day 2 |
120 |
240 |
|||||
3a day 2 |
112 |
224 |
206 ± 25 |
||||
3b day 2 |
94.2 |
189 |
|||||
1a day 3 |
0.003 |
0.008 |
105 |
210 |
212 ± 3 |
210 ± 3 |
2.2 |
1b day 3 |
107 |
215 |
|||||
2a day 3 |
101 |
201 |
206 ± 7 |
||||
2b day 3 |
105 |
210 |
|||||
3a day 3 |
104 |
207 |
211 ± 5 |
||||
3b day 3 |
107 |
215 |
Calculation of water solubility according to ceriumin test item
Sample |
Ce conc. [mg/L] |
Mean Ce conc. [mg/L] |
SD [mg/L] |
Mean Ce all samples [mg/L] |
SD [mg/L] |
Ce in test item [%] |
Calculated amount of test item dissolved on basis of Ce (100% Purity) [mg/L] |
Mean dissolved test item [mg/L] |
SD [mg/L] |
Mean all samples [mg/L] |
SD [mg/L] |
1a day 1 |
225 |
217 |
010 |
216 |
12 |
23.0 |
980 |
942 |
043 |
938 |
51 |
1b day 1 |
231 |
1005 |
|||||||||
1a day 2 |
204 |
887 |
|||||||||
1b day 2 |
214 |
931 |
|||||||||
1a day 3 |
210 |
914 |
|||||||||
1b day 3 |
215 |
933 |
|||||||||
2a day 1 |
213 |
218 |
13 |
925 |
947 |
59 |
|||||
2b day 1 |
226 |
983 |
|||||||||
2a day 2 |
216 |
940 |
|||||||||
2b day 2 |
240 |
1042 |
|||||||||
2a day 3 |
201 |
875 |
|||||||||
2b day 3 |
210 |
915 |
|||||||||
3a day 1 |
220 |
213 |
13 |
958 |
925 |
58 |
|||||
3b day 1 |
222 |
967 |
|||||||||
3a day 2 |
224 |
973 |
|||||||||
3b day 2 |
189 |
820 |
|||||||||
3a day 3 |
207 |
901 |
|||||||||
3b day 3 |
215 |
934 |
Description of key information
Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of ~ 4 g/L test substance for three replicates), a solubility equilibrium was reached. The mean of dissolved cerium concentrations (< 0.22 μm) measured on day 1, 2 and 3 at 20.1 ± 0.3 °C is 216 ± 12 mg/L via ICP-MS, corresponding to a water solubility of 938 ± 51 mg /L test item, based on a cerium content of 23.0 %.
Key value for chemical safety assessment
- Water solubility:
- 938 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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