Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-303-2 | CAS number: 115340-85-7 1 - 4.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-12-19 to 2018-01-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992-07-17
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: R-127 / batch 170825
- Expiration date of the lot/batch: 2019-07-26
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Dark, dry place at room temperature
- Solubility and stability of the test substance in the solvent/vehicle: insoluble
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: - Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Municipal sewage treatment plant, 31137 Hildesheim, Germany
- Storage length: 7 d
- Preparation of inoculum for exposure: The activated sludge was washed twice with chlorine free tap water. After the second washing the settled sludge was resuspended in mineral salts medium and was maintained in an aerobic condition by aera-tion for 2 hours. Thereafter the sludge was homogenized with a blender. After sedimentation the supernatant was decanted and main-tained in an aerobic condition by aeration with CO2-free air for 7 days. 15 mL/L were used to initiate inoculation.
- Pretreatment: see above
- Concentration of sludge: 15 mL/L
- Initial cell/biomass concentration: Approx. 107 - 108 CFU/L
- Water filtered: no
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 19 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral salts medium according to OECD 301 F
- Test temperature: Nominal: 20 - 24, ± 1 °C; Actual: 20.8 – 21.1 °C
- pH: 7.0 at start, 7.61 and 7.62 at end of experiments
- pH adjusted: no
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: brown glass botttles
- Number of culture flasks/concentration: 2 for inoculum control, 1 for functional control, 2 for test item, 1 for toxicity control
- Method used to create aerobic conditions: aeration
- Measuring equipment:
OxiTop OC110 controller with software Achat OC, WTW
OxiTop measuring heads, WTW
Stirring platform, WTW
Climatic exposure test cabinet, RUMED RUBARTH APPARATE GMBH pH-Meter, Multi 350i, WTW
Datalogger 174 T, TESTO
Analytical balance, SARTORIUS
Balance, KERN
- Test performed in closed vessels due to significant volatility of test substance: no
- Test performed in open system:
- Details of trap for CO2 and volatile organics if used: A rubber sleeve with soda lime was hung into the opening of the bot-tles to absorb evolved CO2. The bottles were closed with
OxiTop measuring heads and the measuring system was activated (toxicity control)
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Functional control: yes
- Toxicity control: yes
- Reference substance:
- benzoic acid, sodium salt
- Test performance:
- The temperature in the incubator was documented continuously throughout the test.
At test start the pH-values of the prepared solutions in the measuring flasks (inoculum control and functional control) and the prepared so-lutions in the separate replicates (test item and toxicity control), were determined. At test end the pH-values of the test solutions in the brown glass bottles were determined. - Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 65
- Sampling time:
- 28 d
- Details on results:
- Theoretical Oxygen Demand
The biodegradation in % was calculated based on the ThOD of 2.67 mg O2/mg test item.
Colony Forming Units of the Inoculum
Colony forming units (CFU) of the inoculum were determined prior to test start by standard dilution plate count: 1.52 x 109 CFU/L. The CFU concentration of the inoculum corresponds to approx.
1.52 x 107 CFU/L in the final test solution.
Results of the Functional Control
The pass level for ready biodegradation (≥ 60% degradation) was reached within 3 days. The validity criterion that the degradation should be ≥ 60% after 14 d was fulfilled.
Stages of Biodegradation: The adaptation phase changed to degradation phase within 2 days (degradation > 10%), with a maximum of 84% on day 26.
Results of the Toxicity Control
In the toxicity control the biodegradation achieved 69% after 14 days, with 77% after 28 days. The validity criterion that the test item should not inhibit the biodegradation of the ref-erence item was fulfilled.
Course and Stages of Biodegradation of Functional Control and Test Item
The mean of replicates reached the 10% level (beginning of biodegradation) on day 2 and the 60% pass level was reached on day 17. The mean biodegradation on day 28 was 65%.
After a test period of 28 days, the test item is classified as readily biodegradable within the 28 day period of the study. - Key result
- Parameter:
- ThOD
- Value:
- 2.67 mg O2/g test mat.
- Results with reference substance:
- Results of the Functional Control
The pass level for ready biodegradation (≥ 60% degradation) was reached within 3 days. The validity criterion that the degradation should be ≥ 60% after 14 d was fulfilled.
Stages of Biodegradation: The adaptation phase changed to degradation phase within 2 days (degradation > 10%), with a maximum of 84% on day 26. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- The test item is classified as readily biodegradable within the 28 day period of the study.
- Executive summary:
The ready biodegradability of the test item 4,4’-Isopropylidenediphenol,ethoxylated, esters with fatty acids, coco was determined with non-adapted activated sludge in the Manometric Respirometry Test for a period of 28 days. The study was conducted according to OECD guideline 301 F.
The test item is classified as readily biodegradable within the 28 day period of the study.
Reference
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.