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Diss Factsheets
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EC number: 431-090-3 | CAS number: 190085-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Salicylate derivatives such as the subject material are expected to be well absorbed following oral or inhalation exposures but poorly absorbed following dermal exposures. Once absorbed, metabolism is expected to be rapid with elimination predominantly through the urine. Bioaccumulation is not expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
The metabolic fates of a number of salicylate esters have been investigated, including the structurally similar 2 -ethylhexyl salicylate (CAS 118 -60 -5), and have been found to be rapidly and completely metabolized by esterases common in many tissues including skin, plasma, liver and other body tissues (Belsito et al., 2007). The products of this metabolism are salicylic acid and the corresponding alcohol. Salicylic acid is rapidly and completely eliminated in a number of species with elimination almost exclusively in the urine (Belsito et al., 2007). Although information is lacking, it is assumed that the alcohol metabolite, 2 -hexyloctyl aclcohol, will be rapidly metabolized and eliminated and, due to low toxicity, will not contribute to the toxicological hazard of the subject material (OECD, 2006). The oral bioavailability of the subject material is assumed to be 100%. Although inhalation toxicokinetic data is lacking, it is presumed that absorption following inhalation exposures will equal that of oral exposures (100%). Based on physical-chemical properties as well as limited data for similar salicylate esters, dermal absorption of the subject material is expected to be low. A conservative estimate of 10% is assigned for dermal absorption. Regardless of route of exposure, bioaccumulation of the subject material or its metabolites is not anticipated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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