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EC number: 270-390-7 | CAS number: 68427-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reported study with only very basic data given; comparable to guideline/standard
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA, Federal Register (17 Sep 1964, 191.12)
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Decyl dihydrogen phosphate, potassium salt
- EC Number:
- 270-390-7
- EC Name:
- Decyl dihydrogen phosphate, potassium salt
- Cas Number:
- 68427-32-7
- Molecular formula:
- C10H23O4P.xK
- IUPAC Name:
- potassium decyl hydrogen phosphate
- Details on test material:
- Name of test compound: TL 522, 45% a.s.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no info
- Age at study initiation: no info
- Weight at study initiation: no info
- Housing: no info
- Diet (e.g. ad libitum): no info
- Water (e.g. ad libitum): no info
- Acclimation period: no info
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no info
- Humidity (%): no info
- Air changes (per hr): no info
- Photoperiod (hrs dark / hrs light): no info
IN-LIFE DATES: October 1974
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
VEHICLE: not used - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 24, 48 and 72 h, day 4, day 7 and in one animal also on days 14 and 21
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM:
CORNEA
Degree of Opacity (most dense area used)
No opacity 0
Scattered or diffuse areas, details of iris clearly visible 1
Easily discernible translucent areas, details of iris slightly obscured 2
Nacreous areas, no details of iris visible, size of pupil barely discernible 3
Opaque cornea, iris not discernible 4
IRIS
Normal 0
Folds above normal, congestion, swelling, circumcorneal injection
(any or all of these or combination of any thereof), iris still reacting to light
(sluggish reaction is positive) 1
No reaction to light, haemorrhage, gross destruction (any or all of these) 2
CONJUNCTIVAE
Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris)
Vessels normal 0
Vessels definitely injected above normal 1
More diffuse, deeper crimson red, indiviual vessels not easily discernible 2
Diffuse beefy red 3
Chemosis
No swelling 0
Any swelling above normal (includes nictitating membrane) 1
Obvious swelling with partial eversion of lids 2
Swelling with lids about half closed 3
Swelling with lids more than half closed 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: days 2/3/4
- Score:
- 1.44
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days (1/3 animals)
- Remarks on result:
- other: 2/3 animals sacrificed on day 7 because of the severity of the response
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: days 2/3/4
- Score:
- 0.78
- Max. score:
- 2
- Reversibility:
- fully reversible within: 4 days (1/3 animals)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: days 2/3/4
- Score:
- 2.11
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days (1/3 animals)
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: days 2/3/4
- Score:
- 2.56
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days (1/3 animals)
- Irritant / corrosive response data:
- Cornal opacities developed in all three animals, and an opacity was still present in one animal on day 21. The remaining two animals were sacrificed on day 7 due to the severity of the response. lritis was observed in all three animals. A diffuse crimson to beefy
red colouration of the conjuntivae and considerable swelling with the eyelids about half closed was observed in all three animals. - Other effects:
- Not reported.
Any other information on results incl. tables
Summary of ocular lesions
Anim. No. |
Effect |
Days after application |
Mean score cornea Days 2/3/4* |
Mean score iritis Days 2/3/4* |
Mean score redness Days 2/3/4* |
Mean score chemosis Days 2/3/4* |
||||||
1 |
2 |
3 |
4 |
7 |
14 |
21 |
||||||
1 |
Cornea* Iris Redness Chemosis |
1 1 2 2 |
1 1 2 2 |
1 1 2 3 |
2 0 2 2 |
4 0 1 1 |
3 0 1 1 |
2 0 1 0 |
1.33 |
0.67 |
2 |
2.33 |
2 |
Cornea* Iris Redness Chemosis |
1 0 2 2 |
1 0 2 2 |
1 1 3 3 |
4 1 2 3 |
4 1 2 3 |
nm |
nm |
2 |
0.67 |
2.33 |
2.67 |
3 |
Cornea* Iris Redness Chemosis |
1 0 1 2 |
1 1 2 2 |
1 1 2 3 |
1 1 2 3 |
4 1 2 3 |
nm |
nm |
1 |
1 |
2 |
2.67 |
Mean all anim. |
1.44 |
0.78 |
2.11 |
2.56 |
nm = not measured as animals had been sacrificed; * score on days 2/3/4 was averaged as signs were generally more severe on day 4 than on day 1
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- As the changes in the eye were not reversible within 21 days in one animal, and the other 2 animals were sacrificed on day 7 because of the severity of the response, the test compound was considered a serious irritant to the rabbit eye.
- Executive summary:
A study was performed to assess the irritancy potential of the test material consisting of 45% decylphosphoric acid, potassium salt (CAS 68427-32-7) to the eye of the rabbit (strain not specified). A single application of the test material to the eye of three rabbits produced serious irritation. The treated eye of one animal was still not normal 21 days after application; the other 2 animals were sacrificed on day 7 due to the severity of the response. The test material requires classification in Category 1 according to OECD-GHS.
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