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EC number: 945-713-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Test method according to OECD guideline 305 C. No data on GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Test temperature:
- 25 °C
- Nominal and measured concentrations:
- 15 µg/L and 1.5 µg/L.
- Reference substance (positive control):
- not specified
- Lipid content:
- 4.2 %
- Key result
- Conc. / dose:
- 15 µg/L
- Temp.:
- ca. 25 °C
- Type:
- BCF
- Value:
- >= 432 - <= 922 L/kg
- Key result
- Conc. / dose:
- 1.5 µg/L
- Temp.:
- ca. 25 °C
- Type:
- BCF
- Value:
- >= 606 - <= 1 290 L/kg
- Validity criteria fulfilled:
- not specified
- Conclusions:
- BCF values of 432 -922 L/kg and 606 -1290 L/kg were measured in fish for Camphene at concentrations of 15 and 1.5 µg/L, respectively.
- Executive summary:
BCF values of 432 -922 L/kg and 606 -1290 L/kg were measured in fish for Camphene at concentrations of 15 and 1.5 µg/L, respectively, using carp (Cyrpinus carpio) which were exposed over a 8 -week period. Test method was according to OECD guideline 305 C.
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M., Howard, P.H, Aronson, D., Printup, H. and S. Gouchie. 1997. "Improved Method for Estimating Bioconcentration Factor (BCF) from Octanol-Water Partition Coefficient", SRC TR-97-006 (2nd Update), July 22, 1997; prepared for: Robert S. Boethling, EPA-OPPT, Washington, DC; Contract No. 68-D5-0012; prepared by: ; Syracuse Research Corp., Environmental Science Center, 6225 Running Ridge Road, North Syracuse, NY 13212.
Meylan, W.M., Howard, P.H., Boethling, R.S. et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999). - Specific details on test material used for the study:
- SMILES: C(C(CC1C2)C2)(C1(C)C)=C
- Key result
- Type:
- BCF
- Value:
- 282.7 L/kg
- Remarks on result:
- other: (Log BCF from regression-based method = 2.451; log Kow used: 4.22)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of D-camphene was 282.7 L/kg wet-wt (log BCF from regression-based method = 2.451).
- Executive summary:
Using the BCFBAF v3.01 model of EPI Suite v4.11, the BCF of D-camphene was 282.7 L/kg wet-wt (log BCF from regression-based method = 2.451).
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M., Howard, P.H, Aronson, D., Printup, H. and S. Gouchie. 1997. "Improved Method for Estimating Bioconcentration Factor (BCF) from Octanol-Water Partition Coefficient", SRC TR-97-006 (2nd Update), July 22, 1997; prepared for: Robert S. Boethling, EPA-OPPT, Washington, DC; Contract No. 68-D5-0012; prepared by: ; Syracuse Research Corp., Environmental Science Center, 6225 Running Ridge Road, North Syracuse, NY 13212.
Meylan, W.M., Howard, P.H., Boethling, R.S. et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999). - Specific details on test material used for the study:
- SMILES: C(CC1C2)C(C2=C)C1(C)C
- Key result
- Type:
- BCF
- Value:
- 343 L/kg
- Remarks on result:
- other: (Log BCF from regression-based method = 2.535; log Kow used: 4.35)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of fenchene was 343 L/kg wet-wt (log BCF from regression-based method = 2.535).
- Executive summary:
Using the BCFBAF v3.01 model of EPI Suite v4.11, the BCF of D-camphene was 343 L/kg wet-wt (log BCF from regression-based method = 2.535).
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M., Howard, P.H, Aronson, D., Printup, H. and S. Gouchie. 1997. "Improved Method for Estimating Bioconcentration Factor (BCF) from Octanol-Water Partition Coefficient", SRC TR-97-006 (2nd Update), July 22, 1997; prepared for: Robert S. Boethling, EPA-OPPT, Washington, DC; Contract No. 68-D5-0012; prepared by: ; Syracuse Research Corp., Environmental Science Center, 6225 Running Ridge Road, North Syracuse, NY 13212.
Meylan, W.M., Howard, P.H., Boethling, R.S. et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999). - Specific details on test material used for the study:
- SMILES: C(C(CC1C2)C1(C)C)(=C2)C
- Key result
- Type:
- BCF
- Value:
- 394.9 L/kg
- Remarks on result:
- other: (Log BCF from regression-based method = 2.597; log Kow used: 4.44)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of L-alpha pinene was 394.9 L/kg wet-wt (log BCF from regression-based method = 2.597).
- Executive summary:
Using the BCFBAF v3.01 model of EPI Suite v4.11, the BCF of L-alpha pinene was 394.9 L/kg wet-wt (log BCF from regression-based method = 2.597).
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M., Howard, P.H, Aronson, D., Printup, H. and S. Gouchie. 1997. "Improved Method for Estimating Bioconcentration Factor (BCF) from Octanol-Water Partition Coefficient", SRC TR-97-006 (2nd Update), July 22, 1997; prepared for: Robert S. Boethling, EPA-OPPT, Washington, DC; Contract No. 68-D5-0012; prepared by: ; Syracuse Research Corp., Environmental Science Center, 6225 Running Ridge Road, North Syracuse, NY 13212.
Meylan, W.M., Howard, P.H., Boethling, R.S. et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999). - Specific details on test material used for the study:
- SMILES: C(C(CC1C2)C2)(C1(C)C)=C
- Key result
- Type:
- BCF
- Value:
- 282.7 L/kg
- Remarks on result:
- other: (Log BCF from regression-based method = 2.451; log Kow used: 4.22)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of L-camphene was 282.7 L/kg wet-wt (log BCF from regression-based method = 2.451).
- Executive summary:
Using the BCFBAF v3.01 model of EPI Suite v4.11, the BCF of L-camphene was 282.7 L/kg wet-wt (log BCF from regression-based method = 2.451).
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue substance camphene which shares the same functional groups with the main components of the multi-constituent substance reaction mass of fenchene and laevo camphene and dextro camphene and laevo alpha pinene also has comparable values for the relevant molecular properties.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Lipid content:
- 4.2 %
- Key result
- Conc. / dose:
- 15 µg/L
- Temp.:
- ca. 25 °C
- Type:
- BCF
- Value:
- >= 432 - <= 922 L/kg
- Remarks on result:
- other: read-across from an analogue for which BCF =432-922 L/kg
- Key result
- Conc. / dose:
- 1.5 µg/L
- Temp.:
- ca. 25 °C
- Type:
- BCF
- Value:
- >= 606 - <= 1 290 L/kg
- Remarks on result:
- other: read-across from an analogue for which BCF =606-1260 L/kg
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from experimental data on the analogue camphene, the BCF value of the reaction mass was determined as a maximum of 1290 L/kg.
- Executive summary:
BCF values of 432 -922 L/kg and 606 -1290 L/kg were measured in fish for Camphene at concentrations of 15 and 1.5 µg/L, respectively, using carp (Cyrpinus carpio) which were exposed over a 8 -week period. Test method was according to OECD guideline 305 C. Based on these results, the read-across approach was applied and the BCF of the reaction mass was determined as a maximum of 1290 L/kg.
Referenceopen allclose all
BCF values of 432 -922 L/kg and 606 -1290 L/kg were measured in fish for Camphene at concentrations of 15 and 1.5 µg/L, respectively.
The BCF of D-camphene was 282.7 L/kg wet-wt (log BCF from regression-based method = 2.451).
The BCF of fenchene was 343 L/kg wet-wt (log BCF from regression-based method = 2.535).
The BCF of L-alpha pinene was 394.9 L/kg wet-wt (log BCF from regression-based method = 2.597).
The BCF of L-camphene was 282.7 L/kg wet-wt (log BCF from regression-based method = 2.451).
Description of key information
Key study. Read-across approach. Test method OECD guideline 305 C. Based on read-across from experimental data on analogue camphene, the BCF value of the reaction mass was determined as a maximum of 1290 L/kg.
Supporting studies: Data from EPI-Suite, EPA (USA) / BCFBAF v3.01 calculation method. The BCF of the main components of the reaction mass were calculated to be in the range of 283 -395 L/kg.
Key value for chemical safety assessment
- BCF (aquatic species):
- 1 290 L/kg ww
Additional information
Key study. Read-across approach. BCF values of 432 -922 L/kg and 606 -1290 L/kg were measured in fish for Camphene at concentrations of 15 and 1.5µg/L, respectively, using carp (Cyrpinus carpio) which were exposed over a 8 -week period. Test method was according to OECD guideline 305 C. Based on these results, the read-across approach was applied and the BCF of the reaction mass was determined as a maximum of 1290 L/kg.
Supporting studies: Data from EPI-Suite, EPA (USA) / BCFBAF v3.01 calculation method. The BCF of the main components of the reaction mass were calculated to be in the range of 283 -395 L/kg.
According to Annex XIII to REACH, the substance is considered not to fulfil the criterion for bioaccumulation, since the estimated BCF (BCF = 1290 L/kg wet-wt) is < 2000.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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