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Diss Factsheets
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EC number: 215-355-9 | CAS number: 1323-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 007
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 945
Materials and methods
- Objective of study:
- absorption
- excretion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Interpretation of data from a guideline in vivo dietary rodent feeding/metabolism study of a structural analogue, castor oil
- GLP compliance:
- no
- Remarks:
- predates development of GLP
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- Castor oil (CAS 8001-79-4), lot #L-5G30-01, was obtained from Cas Chemical, Inc., Bayonne, NJ. (now owned by Vertellus LLC). Purity analysis indicated that it was consistent with the USP specifications and the reported composition for castor oil: Analysis was conducted by Midwest Research Institute (MRI), in Kansas City, MO, utilizing infrared, UV/Vis and NMR spectroscopy, Karl Fischer water analysis, TLC and HPLC, and a battery of USP standard analyses for castor oil.
Constituent 1
- Specific details on test material used for the study:
- no data
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Adult rats
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- daily for 4-6 weeks
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 other: %
- Remarks:
- castor oil
- Dose / conc.:
- 48.4 other: %
- Remarks:
- castor oil
- No. of animals per sex per dose / concentration:
- not specified. ≥ 3.
- Control animals:
- not specified
- Details on study design:
- Adult rats received a diet containing 48.4% castor oil for 4-6 weeks. Control rats received stock ration only. Feces were collected from 3 rats on the castor oil diet. At the end of the feeding period, excised organs/tissues were ground thoroughly and samples of phospholipid fatty acids were obtained from the liver, small intestine and muscle; glyceride fatty acids were obstained from the liver and fat depots.
Results and discussion
- Preliminary studies:
- No evidence of catharsis in rats fed 48.4% castor oil in the diet (stock ration)
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Ricinoleic acid was found in glycerides and cholesterol esters of the fat depots.
- Type:
- excretion
- Results:
- Fatty acids were excreted
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Ricinoleic acid was absorbed from dietary castor oil and was found as a component acid (up to 7%) of the fatty acids in glycerides in carcass fat depots. The feeding of castor oil did not lead to the appearance of significant amounts of ricinoleic acid in glycerides in the liver, nor in phospholipids of any organ tested (liver, small intestine and skeletal muscle). Total body fat in these three animals was also determined, and it was calculated that 1-2% of absorbed ricinoleic acid was deposited in the fat depots.
- Details on excretion:
- The fatty acids excreted by each of three rats amount to 2.1, 2.2 and 3.6% of those ingested. It is assumed that this is in the animals fed castor oil and refers to ricinoleic acid.
Any other information on results incl. tables
Ricinoleic Acid Content of Phospholipids
|
Ricinoleic Acid content (%) in Control-fed rats |
No. of analyses |
Ricinoleic Acid content (%) in Castor Oil-fed rats |
No. of analyses |
Liver |
1.7 ± 1.1 |
7 |
1.3 ± 0.6 |
9 |
Small intestine |
6.0 ± 4.4 |
4 |
4.9 ± 1.7 |
8 |
Skeletal muscle |
4.0 ± 1.7 |
7 |
3.6 ± 2.9 |
8 |
Ricinoleic Acid Content of Glycerides and Cholesterol Esters in Fat Depots
|
Ricinoleic Acid content (%) in Control-fed rats |
No. of analyses |
Ricinoleic Acid content (%) in Castor Oil-fed rats |
No. of analyses |
Liver |
5.6 ± 4.1 |
5 |
7.2 ± 2.4 |
8 |
Carcass Fat Depots |
0.5 ± 0.5 |
7 |
6.8 ± 4.2 |
11 |
Applicant's summary and conclusion
- Conclusions:
- Castor oil, when given to adult rats as 48.4% of a stock feed for 4-6 weeks, ls absorbed and results in incorporation of ricinoleic acid in the glycerides of carcass fat depots. Approximately 7% of the total fatty acid content of depot fat glycerides was found to be ricinoleic acid. This fatty acid was not found in hepatic glycerides or in phospholipids of the liver, small intestine or skeletal muscle. Castor oil and rcinoleic acid are rapidly metabolized.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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