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EC number: 213-979-6 | CAS number: 1070-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-butanediyl diacrylate
- EC Number:
- 213-979-6
- EC Name:
- 1,4-butanediyl diacrylate
- Cas Number:
- 1070-70-8
- Molecular formula:
- C10H14O4
- IUPAC Name:
- 4-(prop-2-enoyloxy)butyl prop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Butandioldiacrylat
- Analytical purity: > 90 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA
- Weight at study initiation: male: 190-220g; female: 160-190g
- Fasting period before study: 15-20 hours
- Diet: Herlian MRH-Haltung; H. Eggersmann KG
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
0.5 % aqueous carboxymethylcellulose formulation
DOSE (mg/kg) | 2150 | 1470 | 1000| 681 |
conentration % (w/v) | 21.5 | 14.7 | 10.0 | 6.81 |
MAXIMUM DOSE VOLUME APPLIED:
Dose volume: 10 ml/kg - Doses:
- 681, 1000, 1470, 2150 mg/kg bw
- No. of animals per sex per dose:
- 10 (one exception: only 9 female animals for dose 1470 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: at least 14 days
- Frequency of observations: multiple observations after administration up to 5 hours afterwards; then daily (but not on weekends)
- Frequency of weighing: day 2-5, and also on day 7, 13 and 21
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsies were performed on all animes that died or were sacrificed.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 544 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 195 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 336 mg/kg bw
- Mortality:
- male: female: male/female
Dose: 681 (mg/kg bw) 1/10 (10%) 0/10 (0%) 1/20 (5%)
Dose: 1000 (mg/kg bw) 2/10 (20%) 3/10 (30%) 5/20 (25%)
Dose: 1470 (mg/kg bw) 5/10 (50%) 8/9 (88.9%) 13/19 (68.4%)
Dose: 2150 (mg/kg bw) 7/10 (70%) 9/10 (90%) 16/20 (80%) - Clinical signs:
- other: Clinical signs (day 0 is day of application; no time specification in brackets: true for whole observation period) 2150 mg/kg bw: irregular breathing, apathy, gasping (day 0-3), tremor, spastic movement, ruffled fur, aggressiveness (day 15-20), diarrhea (
- Gross pathology:
- animals that died:
Heart: acute dilatation of the vestiubules; acute congestive hyperanemia; Liver: peripheral lobus pattern; Stomach: severe vascular injection; partly reddened with extensive bleeding; intestine: vascular injection, atonic, hematinized and diarrheic content; in some cases substance-related malacia of the mucosa; in some cases prominent bleeding of areas of the mucosa; hydrothorax
sacrificed animals:
stomach: forestomach wall thickened, forestomach agglutination; in some cases so-called "button"-formation; in some cases diverticulum formation
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 in rats for butandioldiacrylate was 1336 mg/kg bw.
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