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EC number: 235-841-4 | CAS number: 13003-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P',P'-tetratridecylbis(phosphine)
- EC Number:
- 235-841-4
- EC Name:
- Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P',P'-tetratridecylbis(phosphine)
- Cas Number:
- 13003-12-8
- Molecular formula:
- C78H144O6P2
- IUPAC Name:
- 4-[2-(4-{[bis(tridecyloxy)phosphanyl]oxy}-5-tert-butyl-2-methylphenyl)pentyl]-5-methyl-2-(propan-2-yl)phenyl ditridecyl phosphite
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Lot No.: 352Y7, Purity = 99.9%. The test material and BBMC were provided by the study sponsor via Chang Chun Petrochemical Co., (CAS No.: 85-60-9, Lot No.: 307Z7, Purity = 99.12%) and was received on 8 January 2018 and stored at room temperature.
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- The sampling was conducted on 6,6'-di-tert-butyl-4,4'-butylidenedi-m-cresol (BBMC), which is a hydrolysis product.
Duration of test
- Duration:
- 7 d
- pH:
- 7
- Temp.:
- 20 °C
- Number of replicates:
- 3
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 6,6'-di-tert-butyl-4,4'-butylidenedi-m-cresol
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 201-618-5]
- CAS number:
- 85-60-9
- Molecular formula:
- C26H38O2
Dissipation DT50 of parent compound
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- < 68.5 h
- Type:
- other: BBMC Recovery
Any other information on results incl. tables
- An HPLC method was established to quantify BBMC with a LOQ of 0.10 mg/L in standard solution.
- Based upon the LOQ and the sample preparation scheme, a DP-1 test concentration (~ 6.5 mg/L) was identified, which ensured that the hydrolysis of 90 mol% of DP-1 dosed to the test vessels could be tracked analytically.
- DP-1 was partially hydrolyzed in neutral buffer (pH = 7.0) to BBMC over 68.5 hours, with a net yield of approx. 30.9% mol%.
- Further experiments are needed to obtain detailed kinetic data for DP-1 hydrolysis with silica gel dispersion method.
Based upon chromatographic peak area counts of BBMC standard solutions, a calibration standard curve (Figure 1) was constructed to determine BBMC concentrations in buffer samples. The calculated BBMC concentrations in 0.05 - 1.00 mg/L standard solutions based on the calibration standard curve were within ±15% of nominal concentrations. However, the base-line resolved peak shape of the 0.05 mg/L BBMC standard solution was not smooth (Appendix I). Therefore, the LOQ for BBMC was estimated to be approximately 0.10 mg/L, equivalent to the concentration of 0.10 mg/L calibration standard which also demonstrated a smooth base-line resolved chromatographic peak (Appendix I). Taking into consideration a dilution factor (2 ×) during sample processing and a correction factor (3.24 ×) for mol% (molecular weight of DP-1/BBMC = 3.24), it was estimated that a test concentration of at least ~6.5 mg/L DP-1 in buffer solution would be necessary to quantify BBMC equivalent to at least 10 mol% applied DP-1 to each test vessel containing a buffer solution.
Figure 2 presents the results of DP-1 hydrolysis over 68.5 hours. BBMC was detected in all samples. For time zero samples, BBMC was about 4.17 mol% in buffer containing DP-1 loaded silica gel and 3.47 mol% in buffer directly mixed with DP-1 stock solution. The presence of BBMC in time zero samples is likely due to the impurity or background level of BBMC in DP-1 test substance. For directly mixing samples, BBMC was increased slightly to 6.07 mol% over 68.5 hours, indicating very little (~ 2.6 mol%) BBMC was released from DP-1. In contrast, BBMC was increased to 35.1 mol% over 68.5 hours, a net increase of ~ 30.9 mol%, suggesting that DP-1 was partially hydrolyzed to BBMC facilitated by silica gel dispersion.
Conclusions
Applicant's summary and conclusion
- Conclusions:
- The test material hydrolyzes based on the formation of BBMC in the testing solutation.
- Executive summary:
The test material hydrolyzes based on the formation of BBMC in the testing solutation.
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