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EC number: 211-941-3 | CAS number: 717-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 21 to Jun 26, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: HJ/f 153-2004, The guidelines for the testing of chemicals [S]. Beijing: SEPA, 2004
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- GLP compliance:
- yes
- Remarks:
- According to the guidelines of chemical testing good laboratory practices in China
- Specific details on test material used for the study:
- Test substance H6362
Lot No: 6F11027000
Purity 96%
Expiry: 2 years
Appearance: Clear high boiling odorless liquid
Storage conditions: Keep container tightly closed. Store away from heat and light. - Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, non-adapted
- Details on inoculum:
- Samples of secondary effluent were obtained as the test inoculum from a sewage plant treating predominantly domestic sewage (Nanjing Chengdong Sewage Treatment Plant).
On the day of the test, the test inoculum was prepared by filtering the sample of sewage effluent through a coarse filter, (discarding the first 200 mL) and collecting the remaining filtrates. This inoculum was maintained under aerobic conditions in hte test area unitl use. The inoculum was not pre-conditioned at test temperature and was not pre-adapted to the test item. The test solutions were prepared in an inorganic mineral medium, inoculated with a small number of micro-organisms from a mixed population. - Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- ca. 2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of test medium: inorganic mineral medium
- Test temperature: 20°C
- pH: 6.68-7.03
- pH adjusted: no
- Aeration of dilution water: Dilution medium prepared by adding 1 mL each of the 4 stock solutions, prepared in pre-aerated deionized water to each litre of deionised water
- Suspended solids concentration: Not specified
- Continuous darkness: yes
- Other:
TEST SYSTEM
- Culturing apparatus: BOD-bottle
- Number of culture flasks/concentration: 4 groups (inoculum control, test group, procedure control, toxicity control): 4 bottles for toxicity control; 20 bottles for each of inoculum control, test group, and reference control
- Method used to create aerobic conditions: Laboratory supply of oil-free compressed air. BOD bottles aerated with hose which reached down to the bottom of the bottle
- Measuring equipment: Analytical balance, dissolved oxygen (DO) meter, pH meter
- Test performed in closed system: Yes, the BOD bottles were fully filled (total volume: 300 mL)
- Other: Test inoculum prepared by fiiltering sample of sewage effluent through coarse filter (first 200 mL discarded) and collecting remaining filtrates
SAMPLING
- Sampling frequency: DO measured made at 0, 2, 5, 7, 11, 14, 18, 21, 25 and 28 days (except for toxicity control - DO, pH, and temp taken at the start and after 14 days)
- Sampling method: DO meter
- Sample storage before analysis: Not specified
CONTROL AND BLANK SYSTEM
- Inoculum blank: contained inoculum only; O2 consumption reached 1.02 mg O2/L after 14d of incubation. Met the test criteria of <1.5 mg O2/L
- Procedure control: contained reference substance and inoculum; biodegradation of reference substance reached 91.6% w/in 14d. Met the test criteria of achieving 60% w/in 14d
- Toxicity control: contained test substance, reference substance, and inoculum. Degradation was 70.3% after 14d. Met the test criteria of no less than 25% in 14d.
STATISTICAL METHODS: Theoretical oxygen demand, oxygen consumption, and % biodegradability calculated - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- sodium benzoate
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 73.3
- Sampling time:
- 28 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 69.65
- Sampling time:
- 25 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 68.6
- Sampling time:
- 21 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 66
- Sampling time:
- 18 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 64.6
- Sampling time:
- 14 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 60.7
- Sampling time:
- 11 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 56.2
- Sampling time:
- 7 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 47.2
- Sampling time:
- 5 d
- Remarks on result:
- other: average value
- Parameter:
- % degradation (O2 consumption)
- Value:
- 5.32
- Sampling time:
- 2 d
- Remarks on result:
- other: average value
- Details on results:
- The results showed that the average biodegradation rate of H6362 was 73.3% after 28-days and about 64% at 10-d window, based on the calculation of ThOD(NO3).
- Results with reference substance:
- The biodegradation of the reference substance achieved 91.6 % within 14 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The study results showed that under the valid conditions, the average biodegradation rate of the test item was 73.3% after 28-days and about 64 % at the 10-d window. It would therefore be considered readily biodegradable, as it achieved the 10-d pass level (60% ThOD) stated in the OECD 301 Method.
- Executive summary:
The study results showed that under the valid conditions, the average biodegradation rate of the test item was 73.3% after 28-days and about 64% at the 10-d window. It would therefore be considered readily biodegradable, as it achieved the 10-day pass level (60% ThOD) stated in the OECD 301 Method.
Reference
The test is valid because the biodegradation of the reference substance achieved 91.6 % within 14 days, meeting the test criteria of achieving 60% within 14 days. Oxygen consumption in inoculated blanks was 1.02 mg O2/L after 14 days of incubation, meeting the test criteria of less than 1.5 mg O2/L. Degradation in the toxicity control was 70.3% after 14 days, meeting the test criteria of no less than 25% in 14 days. The result indicated that the test substance was not toxic to the inoculum. Additionally, the lowest level of dissolved oxygen in test substance group was 2.99 mg O2/L, which did not fall below 0.5 mg O2/L and the difference of biodegradation of the test item in the two replicates was less than 20%. Thus, all validity criteria listed in Section 4.4 were met. Therefore the test is considered valid.
Description of key information
The results showed that the average biodegradation rate of H6362 (test substance) was 73.3% after 28-days and about 64% at 10-day window, based on the calculation of ThOD(NO3).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The REACH Guidance on Information Requirements Chapter R.7b indicates that a pass level of 60% theoretical oxygen demand (ThOD; TG 301 C, TG 301 D and TG 301 F) obtained within 28 days, may be regarded as evidence of ready biodegradability. Therefore, the substance can be considered as readily biodegradable.
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