Registration Dossier
Registration Dossier
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EC number: 309-011-8 | CAS number: 99688-45-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977/78
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- other: BASF Method
- Limit test:
- yes
Test material
- Reference substance name:
- Trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphth[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone
- EC Number:
- 309-011-8
- EC Name:
- Trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphth[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone
- Cas Number:
- 99688-45-6
- Molecular formula:
- C45H17Cl3N2O5
- IUPAC Name:
- 1,2,3-trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphtho[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone
- Test material form:
- solid
- Details on test material:
- Vat Green 13
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Inhalation by means of dust enriched vapor for 8 hours. To achieve enrichment, air was fed through an approx. 5 cm deep layer of the product (weak dust development).
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- enriched atmosphere
- No. of animals per sex per dose:
- 12 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observation, weekly weighing
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology - Statistics:
- NA
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: no effect at saturation concentration
- Mortality:
- None
- Clinical signs:
- other: None
- Body weight:
- NA
- Gross pathology:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 8 hours inhalation of saturated athmosphere did not lead to any deaths in rats (0/12).
- Executive summary:
In an acute inhalation toxicity study, rats were exposed by inhalation to the test item in a saturated atmosphere for 8 hours. No deaths and no gross pathological signs of toxicity were observed.
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