Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-601-5 | CAS number: 51032-53-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- May 12, 1981
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triisooctyl 2,2',2''-[phosphoryltris(thio)]trisacetate
- EC Number:
- 274-011-6
- EC Name:
- Triisooctyl 2,2',2''-[phosphoryltris(thio)]trisacetate
- Cas Number:
- 69452-87-5
- Molecular formula:
- C30H57O7PS3
- Test material form:
- liquid
- Details on test material:
- Generic name: TGE - Phosphite
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414, Fuellinsdorf
- Age at study initiation: 12 - 14 weeks
- Weight at study initiation: 2100-2490 g
- Housing: individually in metal cages
- Diet (e.g. ad libitum): Rabbit food, NAFAG, No. 814 Tox, NAFAG AG, Gossau, SG (Switzerland; ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3° C
- Humidity (%): 30-70 %
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- three females
- Details on study design:
- TEST SITE
- Area of exposure: at least 6 sq. cm
- Type of wrap if used: A gauze patch bearing 0.5 ml of the test substance was applied to the skin and looseli held in place by adhesive but non irritating tape (ISOPLAST AG, CH-5200 Brugg)
OBSERVATION TIME POINTS
- 1, 24, 48 72 hours
SCORING SYSTEM:
- Method of calculation: per guidelines
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 0.5
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: minimal irritation
- Remarks:
- see attached table of results
- Irritant / corrosive response data:
- Grade 2 erythema and Grade 1 oedema was observed in one animal at 1 hour. This animal showed Grade 1 erythema and Grade 1 oedema at 24 hours. A second animal showed Grade 1 erythema at 1 hour. No reactions were seen in the third animal.
- Other effects:
- The animals showed a normal body weight development.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not classified by CLP Criteria
- Conclusions:
- In a guideline (OECD 404) in vivo skin irritation study, TGE Phosphite was found to be a non-irritant to intact rabbit skin. The calculated dermal irritation index was 0.5. All reactions cleared within 48 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
