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EC number: 233-271-0 | CAS number: 10102-43-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- The MAK Collection for Occupational Health and Safety
- Author:
- DFG
- Year:
- 2 014
- Bibliographic source:
- Deutsche Forschungsgemeinschaft (2014),The MAK-Collection Part I, MAK Value Documentations, 37p
- Reference Type:
- publication
- Title:
- Experimental studies on nitric oxide
- Author:
- Gustafsson L
- Year:
- 1 993
- Bibliographic source:
- Gustafsson L (1993), Experimental studies on nitric oxide, Scand J Work Environ Health 1993;19(2):44-49
- Reference Type:
- review article or handbook
- Title:
- Oxydes d'azote - fiche toxicologique n°133
- Author:
- INRS
- Year:
- 2 006
- Bibliographic source:
- INRS (2006), Oxydes d'azote - fiche toxicologique n°133, 9p
- Reference Type:
- other: SDS
- Title:
- Unnamed
- Year:
- 2 015
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrogen monoxide
- EC Number:
- 233-271-0
- EC Name:
- Nitrogen monoxide
- Cas Number:
- 10102-43-9
- Molecular formula:
- NO
- IUPAC Name:
- oxidoamine
Constituent 1
- Specific details on test material used for the study:
- No information on test material in the various sources
Test animals
- Species:
- other: rats and mice
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 112.8 ppm
- Exp. duration:
- 1 h
- Remarks on result:
- other: source: INRS ; species: rats
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 115 ppm
- Exp. duration:
- 1 h
- Remarks on result:
- other: source: EIGA ; species: rats
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 57.5 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: source : SDS ; species: rats
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 320 ppm
- Exp. duration:
- 8 h
- Remarks on result:
- other: source: Gustafsson species: mice
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 128 ppm
- Remarks on result:
- other: source: MAK ; species: rats; exposure duration not mentionned
- Clinical signs:
- other: According to MAK: The formation of MetHb or effects on the central nervous system can be expected after a short-term exposure to NO. These effects have been observed in several studies made on rats and for a wide range of concentrations. According to INR
Any other information on results incl. tables
The various data can be filtered as follows:
- results in mice are ignored (non standard species) as data in rats are available
- results with unknown exposure duration are ignored
Therefore, the most relevant LC50 values in rats are:
- 57.5 ppm /4h
- 112.8-115 ppm /1h
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- According to various consistent sources, the test item has the following LC50 values in rats:
- 57.5 ppm /4h
- 112.8-115 ppm /1h
The classification criteria relate to a 4-hour exposure. According to CLP Regulation, if data for a 4-hour period are not available then extrapolation of the results to 4 hours can be estimated using Haber’s Law : Cnx t = k.
Using a value of n=1 as recommended for extrapolation to longer exposure duration, the two values for 1-hour exposure can be converted into:
- 28.2-28.8 ppm /4h
Overall, three consistent values indicate LC50 values ranging 28.2-57.5 ppm/4h in rats, so based on GHS criteria, the test item is classified as acute inhalation toxicity category 1, H330.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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