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EC number: 412-830-4 | CAS number: 1823-59-2 ODPA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a test according to EU Method B.4, the test item was found to cause very slight erythema one hour after patch removal. The effects were fully reversible within 1 day.
In a test according to EU Method B.5, the test item was found to cause some eye irritation effects that were visible at the inspection 1h after administration. These effects were fully reversible after 1 day. During the observations at 24h and 48h, discharge was observed. All effects were fully reversible within 3 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Vehicle:
- other: acetone
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24h
- Number of animals:
- 6
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Two animals showed very slight erythema (score of 1) one hour after patch removal.
The effects were however fully reversible within 1 day. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not classifed.
- Executive summary:
In a test according to EU Method B.4, the test item was found to cause very slight erythema one hour after patch removal. The effects were fully reversible within 1 day.
Reference
Although a longer exposure time than required by Annex V was employed, the UK c.a. considered the text to be acceptable.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Nature of substance: powder
- Species:
- rabbit
- Strain:
- New Zealand White
- Amount / concentration applied:
- 100 mg
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.6
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.6
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.5
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 72h
- Irritant / corrosive response data:
- The following observations were made after 1h in one or more animals:
- Conjunctival redness (score of 1 or 2)
- Chemosis (score of 1)
- Iris effects (score of 1)
The following observations were made after 24 and 48h in one or more animals:
- Discharge
All effects were fully reversible within 3 days. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not classifed.
- Executive summary:
In a test according to EU Method B.5, the test item was found to cause some eye irritation effects that were visible at the inspection 1h after administration. These effects were fully reversible after 1 day. During the observations at 24h and 48h, discharge was observed. All effects were fully reversible within 3 days.
Reference
In the second test, maximum scores of 1 were recorded for conjunctival redness and other eye effects.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In a test according to EU Method B.4, the test item was found to cause very slight erythema one hour after patch removal. The effects were fully reversible within 1 day. Hence, classification for skin irritation is not required.
In a test according to EU Method B.5, the test item was found to cause some eye irritation effects that were visible at the inspection 1h after administration. These effects were fully reversible after 1 day. During the observations at 24h and 48h, discharge was observed. All effects were fully reversible within 3 days. Based on these findings, classification for eye effects is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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