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Diss Factsheets
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EC number: 222-222-9 | CAS number: 3390-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, an LD50 value of >2000 mg/kg bw was reported (LPT, 2002).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-10 to 2002-08-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Crl: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Germany
- Age at study initiation: males - 42 days; females - 50 days
- Weight at study initiation: males - 219 - 244 g; females - 193 - 200 g
- Fasting period before study: none
- Housing: in groups of 2-3 in MAKROLON cages
- Diet: Standard diet for rats and mice ssniff R/M-H V1530, ad libitum
- Water: drinking water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 55 % +/- 15 %
- Photoperiod (hrs dark / hrs light): 12/ 12 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.87 mL/ kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: the dose used was selected from a series of defined dose levels - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were made before and immediately, at 5, 15, 30 and 60 minutes, as well as at 3, 6, 24 hours after administration. Body weights were recorded before administration and thereafter in weekly intervals up to the end of the study.
- Necropsy of survivors performed: yes. At the end of the study period all the animals were sacrificed, dissected and inspected macroscopically.
- Other examinations performed: changes of skin and fur, eyes and mucous membranes, respiratory and the circulatory, autonomic and central nervous system, somatomotor activity as well as behaviour pattern were observed at least once a day until all the symptoms subsided, thereafter each working day. Attention was also paid to tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma. - Statistics:
- No statistics were used in the study.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the 14-day study period.
- Clinical signs:
- other: No clinical signs of systemic toxicity were noted during the 14-day study period.
- Gross pathology:
- No macroscopic abnormalities were observed at post mortem examination.
- Other findings:
- There were no other findings in the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, an LD50 value of > 2000 mg/kg bw was reported.
- Executive summary:
In the acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, an LD50 value of > 2000 mg/kg bw was reported.
A single dose of 2000 mg/kg bw of undiluted test substance was administered orally to 3 male and 3 female rats. Observations were made before and immediately, at 5, 15, 30 and 60 minutes, as well as at 3, 6, 24 hours after administration. Body weights were recorded before administration and thereafter in weekly intervals up to the end of the 14 -day study. At the end of the study period all the animals were sacrificed, dissected and inspected macroscopically.
No mortality occurred during the 14 -day study period. No signs of systemic toxicity were noted. No macroscopic abnormalities were observed at necropsy.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, an LD50 value of >2000 mg/kg bw was reported (LPT, 2002).
A single dose of 2000 mg/kg bw of undiluted test substance was administered orally to 3 male and 3 female rats. Observations were made before and immediately, at 5, 15, 30 and 60 minutes, as well as at 3, 6, 24 hours after administration. Body weights were recorded before administration and thereafter in weekly intervals up to the end of the 14-day study. At the end of the study period all the animals were sacrificed, dissected and inspected macroscopically.
No mortality occurred during the 14-day study period. No signs of systemic toxicity were noted. No macroscopic abnormalities were observed at necropsy.
Justification for classification or non-classification
Based on the available data for 1,3,5-trimethyl-1,1,3,5,5-pentaphenyltrisiloxane, no classification is required for acute toxicity according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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