Registration Dossier
Registration Dossier
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EC number: 210-194-0 | CAS number: 609-65-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The appraisal of the safety of chemicals in food, drugs and cosmetics, FDA, 1959, p.51
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chlorobenzoyl chloride
- EC Number:
- 210-194-0
- EC Name:
- 2-chlorobenzoyl chloride
- Cas Number:
- 609-65-4
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 2-chlorobenzoyl chloride
- Test material form:
- other: Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Room temperature: 16-18 °C, relative humdity: 40%, Fed: "mümmel z" (sniff/soest) and water ad libitum, light time period: 12h light/ 12h dark, acclimatisation: 7-14 d, BW: 2.3 kg
Test system
- Controls:
- other: the untreated eye served as a control
- Amount / concentration applied:
- 100 µl in the right conjunctiva sac.
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 6 animals
- Details on study design:
- The lids were held tightly after administration for one second. The eyes were not rinsed after the treatment.
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- According to the study the testing substance is highly irritating in the eye (in male rabbits).
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