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EC number: 227-841-8 | CAS number: 6000-43-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-10-16 to 2017-11-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- >= 173.34 - <= 177.56 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- The melting point of the test item was determined within the range of 173.34 and 177.56 °C (446.49 to 450.71 K), which was called the first event.
- Executive summary:
A study was performed according to OECD TG 102 and Commission Regulation (EC). No. 440/2008 method A.1. in order to determine the melting point of the test item by using DSC method. Three determinations were performed since the deviation between the first and second determination was too high (> 0.5 K). Depending on the pre-test the melting point of the test item (first event) was determined to be within the range of 173.34 and 177.56 °C (446.49 to 450.71 K). Within the melting point range the test item melted to a clear colourless solution which returned to its original state after cooling down.
Reference
Pre-Test for melting range
The capillary tube containing the test item was set into the block at 20.9 °C. The block was heated until melting started. The temperature was noted at which the first signs of melting of the test item were observed. When the substance was completely melted, the temperature was noted again.
Table 1: Results of the pre-test
Observations |
Temperature |
The test item began to melt |
176 °C |
The test item was completely melted to a clear colourless solution |
180 °C |
Security Pre-test for the DSC instrument
The test item was charred and escaped at the perforated position after reaching a temperature of 420 °C. The weight was recorded with 47.50 mg. For the additional crucible no visually change after reaching a temperature of 250 °C was visible. The weight was recorded with 46.77 mg.
Calibration
After calibration with indium and zinc the measurement of indium yielded the following values:
Table 2: Values DSC Indium
Expected Melting point |
Measured Melting point |
Expected Energy |
Measured Energy |
Assessment |
156.6 ± 1.0 °C |
156.60 °C |
28.45 ± 1.0 J/g |
27.72 J/g |
OK |
The measurement of indium after calibration met the validity criteria.
DSC Measurement of the Test Item
Table 3: Values DSC Test Item first determination
Temperature [°C] |
Energy |
|
Melting Point |
173.34 (Onset) |
177.75 [J/g] |
The temperature program was adopted in order to cover all expected events for the second and the third determinations.
Table 4: Values DSC Test Item second determination
Temperature [°C] |
Energy |
|
Melting Point |
174.11 (Onset) |
191.51 [J/g] |
The deviation between the first and second determination was too high (> 0.5 K); therefore, a third measurement was performed.
Table 5: Values DSC Test Item third determination
Temperature [°C] |
Energy |
|
Melting Point |
177.56 (Onset) |
190.67 [J/g] |
Observations
Table 6: Values Observations
Mass test item |
Mass crucible (before measurement): |
Mass crucible (after measurement): |
Observations |
|
First Measurement |
1.01 mg |
46.83 mg |
46.49 mg |
The crucible was visually unchanged after measurement |
Second Measurement
|
2.16 mg |
47.59 mg |
46.38 mg |
The crucible was visually unchanged after measurement. The crucible was opened: the test item was charred and the crucible was discolored into black. |
Third Measurement
|
2.18 mg |
48.05 mg |
46.83 mg |
The crucible was visually unchanged after measurement |
Referring to observations in the pre-tests the first endothermic event was stated as melting point.
Presentation of final results
Table 7: Calculated Values
Melting Point |
in °C |
in K |
First Determination |
173.34 |
446.49 |
Second Determination |
174.11 |
447.26 |
Third Determination |
177.56 |
450.71 |
Min |
173.34 |
446.49 |
Max |
177.56 |
450.71 |
|
|
|
Description of key information
The melting point of the test item was determined within the range of 173.34 and 177.56 °C (446.49 to 450.71 K), which was called the first event.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 173.34 °C
Additional information
A study was performed according to OECD TG 102 and Commission Regulation (EC). No. 440/2008 method A.1. in order to determine the melting point of the test item by using DSC method. Three determinations were performed since the deviation between the first and second determination was too high (> 0.5 K). Depending on the pre-test the melting point of the test item (first event) was determined to be within the range of 173.34 and 177.56 °C (446.49 to 450.71 K). Within the melting point range the test item melted to a clear colourless solution which returned to its original state after cooling down (reference 4.2-1).
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