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EC number: 258-887-7 | CAS number: 53956-04-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- estimation method based on individual solubilities in water and octanol as the experimental determination is technically not feasible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- OECD 123 was attempted but low solubility in octanol made the experimental determination technically not feasible.
Therefore, log Pow was estimated by a calculation method based on individual solubilities in water (critical micelle concentration >= 160 mg/L for glycyrrhizic acid) and octanol (determined experimentally as < 20 mg/L). - GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Ammonium glycyrrhizate
- EC Number:
- 258-887-7
- EC Name:
- Ammonium glycyrrhizate
- Cas Number:
- 53956-04-0
- Molecular formula:
- C42H65NO16
- IUPAC Name:
- ammonium glycyrrhizate
Constituent 1
Study design
- Analytical method:
- other: not relevant, estimation method (solubility ratio)
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- <= -0.9
- Remarks on result:
- other: Temperature/pH not indicated
Any other information on results incl. tables
The item was found to have surfactant properties, thus the determination of the partition coefficient of the test item according to OECD 123 was proposed.The preliminary tests showed that the solubility of the test item in octanol is below 20mg/L.
Due to the very low solubility of the test item in octanol, the determination of the log Pow value is not feasible by the OCDE 123 method. Therefore, the Log Pow was estimated by a calculation method based on individual solubilities in water and octanol.
As the test item has surface-active properties, the water solubility should be considered as its critical micelle concentration (CMC). From the water solubilty study (see section 4.8.), the CMC of the test item is estimated to be 5 g/L. In the literature, some CMC values were measured (from the glycyrrhizic acid) between 0.16 to 4.4 g/L.
Since it was observed during the preliminary tests that the test item solubility in octanol was below 20 mg/L(exact value not determined), and the test item CMC value is higher than 160 mg/L (according to the literature), the maximal value of the log Pow can be estimated by the following calculation:
log Kow = log (solubilty in octanol/solubilty in water) <= log(20/160) <= -0.9
Applicant's summary and conclusion
- Conclusions:
- The log Pow of test item could not be determined experimentally due its surfactant properties and the low solubility in octanol. Therefore, the Log Pow was estimated by a calculation method based on individual solubilities in water and octanol. A maximal value of - 0.9 was calculated from the ratio of the measured solubility in octanol (<20 mg/L) and water (CMC of 160mg/L).
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