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EC number: 679-769-5 | CAS number: 2675-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2014-02-03 to 2014-02-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch No.: DEAA-P
Purity: 99.95% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Sample storage conditions before analysis: kept in a refrigerator (2~8 °C ), the test solution be pr epared just prior to the exposure. - Vehicle:
- no
- Details on test solutions:
- Preparation of test solution
-Preliminary test (solution test): prior to range-finding and limit test, solubility test was conducted to identify the solubility of test in dilution water (M4 medium). As a result of solubility test, it's identified that the test substance is soluble with dilution water (M4 medium) at the concentration of 500 mg/L.
-Range finding and limit test: the range finding and limit test are conducted at the nominal concen tration of 27.908, 33.490, 40.188, 48.225, 57.870, 69.444 and 100 mg/L. Each test solution of nominal concentration was prepared by dil ution of stock solution in the morning of exposure date.
-Definitive test: the definitive test be conducted at the nominal concentration of 100 mg/L on the basis of range finding and limit test. Each test solution of nominal concentration was prepared by dilution of stock solution in the morning of exposure date.
TEST method: analysis of the test substance in the range-finding and limit test was carried out by preliminary test according to the SOP for the stability test. As the results of stability test, the concentration changes of test sub stance in nominal concentration (27.908 and 100 mg/L) after 48h were 3.2 and -1.2%, respectively. On the basis of the stability, the definitive test was carried out using static-system. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: Risk Assessment Division, National Institute of Environmental Research
- Selection of test species: Young daphnids for test were derivied from healthy brood stock of Daphnia magna, deliverd more than three times. At the start of the test, they were aged less than 24 hours.
- Feed: cultures were fed daily with the green algae suspension once a day and the amount of feed was range of 0.4~0.5 mL per culture. - Test type:
- static
- Water media type:
- other: dilution water (M4 medium)
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 228 ~ 240 mg/L (as CaCO3)
- Test temperature:
- 19.7 ~ 20 °C
- pH:
- 7.99 ~ 8.1
- Dissolved oxygen:
- 7.89 ~ 7.98 mg/L
- Nominal and measured concentrations:
- nominal concentration: 100 mg/L
measured concentration: 99.999 mg/L - Details on test conditions:
- TEST SYSTEM
- test concentration: 100 mg/L
- control: OECD M4 medium
- replicate: four replicates per test concentration and control
- number of daphnids: five daphnids per replicate
- test solution volume: 10 mL test solution per daphnid
-Control: OECD M4 medium was used for the negative control.
-Replicate: four replicates per test concentration and control
-number of daphnids: five daphnids per replicate
-test solution: 10 ml test solution per daphnid - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Immobilization and abnormal behavior: there were no immobility and abnormal behavior in the negative control and nominal concentration of 100 mg/L.
Appearance: all the test solution were kept clear from the beginning to the end of exposure. - Results with reference substance (positive control):
- 24h EC50 based on the nominal and measured concentration were 1.735 mg/L (95% confidence limit: 1.464 ~ 2.1 mg/L) and 1.703 mg/L (95% confidence limit: 1.439 ~ 2.058 mg/L), respectively.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 24h and 48h EC50 of test item based on nominal concentration were great than 100 mg/L.
The 24h and 48h EC50 of test item based on measured concentration were great than 99.999 mg/L. - Executive summary:
The study was performed to assess the acute toxicity effect of test item to Daphnia magna according to the OECD Guideline for Testing of Chemicals No. 202 (2004).
1) The definitive test was carried out using static system on the basis of stability test.
2) During the test period, temperature, pH and dissolved oxygen of the test solution were 19.7 ~ 20 °C, 7.99 ~ 8.10 and 7.89 ~ 7.98 mg/L, respectively.
3) Hardness and Alkalinity of test solution were 228 ~ 240 mg/L (as CaCO3) and 48 ~ 50 mg/L.
4) All the test solutions were kept clear from the beginning to the end of test.
5) The geometric mean of measured concentration for test item in the nominal concentration (100 mg/L) was 99.999 mg/L.
The results of acute toxicity for test item, the 24h and 48h EC50 of test item based on nominal concentration were great than 100 mg/L, the 24h and 48h EC50 of test item based on measured concentration were great than 99.999 mg/L.
Reference
Description of key information
The 24h and 48h EC50 of test item based on nominal concentration were great than 100 mg/L (measured concentration 99.999 mg/L).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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