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Diss Factsheets
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EC number: 947-436-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction product of tetrahydro-2,5-dimethoxy furan, ethanol and water
- EC Number:
- 947-436-6
- Molecular formula:
- not applicable for UVCB
- IUPAC Name:
- Reaction product of tetrahydro-2,5-dimethoxy furan, ethanol and water
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 10 weeks
- Weight at study initiation: not reported
- Fasting period before study: not reported
- Housing: groupwise n=3 in Makrolon cages type IV
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 4 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-2
- Humidity (%): 55+/-15
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- > 1.49 - < 2.2 µm
- Remark on MMAD/GSD:
- MMAD was 1.49 μm (group 1, 500 mg/m3), 1.53 (group 3, 500mg/m3 repeated) and 2.2 μm (group 2, 1000 mg/m3), resp.
- Details on inhalation exposure:
- The exposure atmosphere for the study was generated by spraying the RP solution into a continuous air flow with air supplied from the animal hause air conditioning system. After spraying parts of the solution immediately evaporate.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- concentrations of 1078 (group 2, 1000 mg/m3 ), 346 mg/m3 (group 1, 500 mg/m3) and 596 mg/m3 (group 3, 500 mg/m3 repeated).
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 2 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No effects observed
- Clinical signs:
- other: Slight effects like soiled coat and red stains, all reversible within recovery period.
- Body weight:
- Body weight was slightly decreased until day 3 in both sexes of group 1 (500 mg/m3) and 3 (500 mg/m3 repeated) and markedly decreased until day 3 in both sexes of group 2 (1000m.g/3) and returned to normal afterwards.
- Gross pathology:
- No findings were observed in males and females of group 1 (500 mg/m3) and group 3 (500mg/m3 repeated).
In group 2 (1000 mg/m3) one female showed findings in the lung (spongy consistency, dark red) and slightly enlarged adrenals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the study findings in rats perfomed according to the OECD Guideline 436, the test item will be classified under Category 4 of the actual Globally Harmonized System of Classification and Labelling of Chemicals. The LC50 cut-off therefore is 2000 mg/m3 (2 mg/L).
- Executive summary:
The aim of the study was to determine the acute inhalation toxicity of the reaction product of DMO-THF, water and ethanol following nose-only exposure according to the OECD Guideline 436. Nine male and nine female Wistar (WU) rats, approximately 12 weeks old at the day of exposure, purchased from Charles River Deutschland, Sulzfeld, Germany, were exposed for 4 hours to the test item (reaction product of DMO-THF, water and ethanol) at three concentrations.
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