Registration Dossier
Registration Dossier
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EC number: 220-744-1 | CAS number: 2885-00-9
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Using a structural anlogue of tertiododecylmercaptan for ODM. It has the same terminal thiol (-SH) group which determines its biochemical activity (i.e. aquatic toxicity) and has a slightly shorter alkyl chain length which means it will be more likely to penetrate cellular membranes but will still be highly water insoluble just like ODM.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- DIN 38412-8 (Pseudomonas Zellvermehrungshemmtest)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- tert-dodecanethiol
- EC Number:
- 246-619-1
- EC Name:
- tert-dodecanethiol
- Cas Number:
- 25103-58-6
- Molecular formula:
- C12H26S
- IUPAC Name:
- 2-methylundecane-2-thiol
- Test material form:
- liquid
Constituent 1
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Pseudomonas putida
Study design
- Test type:
- not specified
Test conditions
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 16 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 10 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- > 10 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- not specified
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The results from TDM show that the EC50 value is >10g/L which is well above the quoted water solubility of TDM of 0.25m/L. As TDM is a shorter chain version of ODM then it is valid to assume that ODM will exhibit similar behaviour so we have quoted the EC50 figure as it is scientifically justifiable to do this as the only diference between the structures is the longer alkyl chain which will affect the overall water solubility but will not affect the efficacy of the terminal thiol (-SH) which is the active common functional group in both compounds.
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