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EC number: 210-862-1 | CAS number: 624-78-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February -September 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethyl(methyl)amine
- EC Number:
- 210-862-1
- EC Name:
- Ethyl(methyl)amine
- Cas Number:
- 624-78-2
- Molecular formula:
- C3H9N
- IUPAC Name:
- ethyl(methyl)amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- No. of animals per sex per dose:
- 20
- Details on study design:
- The test substance was administered by oral route at dose levels of 200 or 2000 mg/kg to 2 groups of 10 fasted Sprague-Dawley rats (5 males and 5 females in each). The test substance was administered as an aqueous solution at 200 mg/kg at a volume of 10 ml/kg, or in its original form at 2000 mg/kg taking into consideration that the specific gravity (SG) of the test substance was 0.6877. The mortality, general behaviour and body weight gain of the animals were observed for a period of 14 days after the single administration of the test substance. A necropsy was performed on each animal found dead during the study or sacrificed at the end of the study.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occured at 200 mg/kg. At 2000 mg/kg, a clear decrease in spontaneous activity associated with respiratory difficulties preceded the death of all animals which orccured within 2 hours of treatment.
- Clinical signs:
- other: clear decrease in spontaneous activity associated with respiratory difficulties preceded the death of all animals which orccured within 2 hours of treatment.
- Gross pathology:
- no abnormalities at 200 mg/kg. Redness of the stomach and intestinal mucosa was observed in all of the naimlas given 200 mg/kg which were found dead during the study.
Any other information on results incl. tables
The general behaviour and body weight gain of the animals
were not affected by administration of the test substance at
200 mg/kg. No deaths occurred at 200 mg/kg.
At 2000 mg/kg, a clear decrease in spontaneous activity,
associated with respiratory difficulties, preceded the death
of all the animals, which occurred within 2 hours of
treatment.
The macroscopic examination revealed no abnormalities in the
animals given 200 mg/kg which were sacrificed at the end of
the study. Redness of the stomach and intestinal mucosa was
observed in all of the animals given 2000 mg/kg which were
found dead during the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
The LD50 of ETHYLMETHYLAMINE administered by oral route in
rats was between 200 mg/kg (0% mortality) and 2000 mg/kg
(100% mortality).- Executive summary:
The test substance was administered by oral route at dose
levels of 200 or 2000 mg/kg to 2 groups of 10 fasted
Sprague-Dawley rats (5 males and 5 females in each). The
test substance was administered as an aqueous solution at
200 mg/kg at a volume of 10 ml/kg, or in its original form
at 2000 mg/kg taking into consideration that the specific
gravity (SG) of the test substance was 0.6877.Under our experimental conditions, the LD50 of the test susbtance ETHYLMETHYLAMINE administered by oral route in rats was between 200 mg/kg (0 mortality) and 2000 mg/kg (100% mortality)
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