Registration Dossier
Registration Dossier
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EC number: 233-465-5 | CAS number: 10191-18-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Although only sparce details on methods, conclusions have been made that there is no apparent potential for skin sensitisation.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- Non-maximised repeat application
- Principles of method if other than guideline:
- Guinea pigs treated at concentrations of 5% to 100% solutions once a week for 3 weeks.
Repeated challenges at 25% to 100% at 1 - 3 weeks. - GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Historical data, but accepted as valid for US NTP.
Test material
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- Molecular formula:
- C6H15NO3
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
Constituent 1
- Specific details on test material used for the study:
- Purity and source not specified
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- 5% - 100%
- Day(s)/duration:
- 21
- Adequacy of induction:
- highest technically applicable concentration used
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- Up to 100%
- Day(s)/duration:
- 21
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- Not specified
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- other: Not specified
- Group:
- test chemical
- Dose level:
- 100%
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Although methods and details of results not specified, the information is considered acceptable for the US NTP.
Note that triethanolamine is widely used in cosmestics and is not listed as a potential allergen.
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