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Diss Factsheets
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EC number: 915-640-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Three oral and one dermal acute toxicity studies are available for the REACH-registered substance. This acute toxicity dataset is supplemented with the publically available secondary reference data on the REACH-registered substance and key information on the ADPODS category members (refer to full read-across ADPODS category justification document). No acute inhalation data are available for any of the ADPODS category members; however, as these have low vapor pressures, no inhalation exposures are expected.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three female Fischer 344 rats received the test material, as a 20% aqueous solution, by single dose oral gavage, at dose levels of 1500 or 2000 mg/kg.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No additional data
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Rats received the test material, as a 20% aqueous solution, by single dose oral gavage.
- Doses:
- 1500 and 2000 mg/kg
- No. of animals per sex per dose:
- 3 females/dose
- Control animals:
- no
- Details on study design:
- Three female Fischer 344 rats received the test material, as a 20% aqueous solution, by single dose oral gavage, at dose levels of 1500 or 2000 mg/kg. In-life observations and body weights were recorded over a 2-week observation period.
- Statistics:
- None
- Preliminary study:
- No data
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 500 - < 2 000 mg/kg bw
- Mortality:
- No rats died at 1500 mg/kg and 2 out of 3 died at 2000 mg/kg.
- Clinical signs:
- other: In-life signs of toxicity observed on both dose groups included diarrhea. Lethargy, palpebral closure, and facial soiling (reddish color) were observed in the high dose animals only.
- Gross pathology:
- No data
- Other findings:
- None
- Interpretation of results:
- Toxicity Category IV
- Conclusions:
- The acute oral LD50 for female rats was between 1500 and 2000 mg/kg.
- Executive summary:
The test material, XU-40340.00 DOWFAX 3B2, powder form, was submitted by the Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company, Midland, MI. The material is of interest for use in the agriculture, cleaning, and textile industries. Standard acute toxicologic tests were conducted and included the acute oral toxicity, skin irritation, and eye irritation studies. The acute, oral LD50 for female Fischer 344 rats was between 1500 and 2000 mg/kg. Therefore, the acute oral toxicity of the test material was categorized as low.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 500 mg/kg bw
- Quality of whole database:
- acceptable
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single application of 2000 mg/kg of neat Dowfax 3B2 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Residual test material was washed off when the bandages were removed 24 hours after application, and the animals were collared until dry to prevent grooming of the application site. Observations and body weights were recorded over a 2-week period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- In the acute dermal absorption test, animals were prepared 24 hours prior to dosing by clipping the trunk.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- A single application of 2000 mg/kg of neat Dowfax 3B2 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Residual test material was washed off when the bandages were removed 24 hours after application, and the animals were collared until dry to prevent grooming of the application site.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2 male rabbits
- Control animals:
- no
- Details on study design:
- A single application of 2000 mg/kg of neat Dowfax 3B2 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Residual test material was washed off when the bandages were removed 24 hours after application, and the animals were collared until dry to prevent grooming of the application site. Observations and body weights were recorded over a 2-week period.
- Statistics:
- None
- Preliminary study:
- No data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: Erythema, edema and bums were observed, at the application site, immediately after removing the wrap. These observations were observed through test day four. By test day eight, both animals were observed with scaling, which persisted through the end of th
- Gross pathology:
- None
- Other findings:
- None
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- The estimated acute dermal LD50 for male New Zealand White rabbits was greater than 2000 mg/kg.
- Executive summary:
A sample of Dowfax 3B2 solution surfactant was submitted by Specialty Chemicals, The Dow Chemical Company, Midland. MI for evaluation of acute oral and dermal toxicity and skin and eye irritation. This compound is a potential ingredient in cleaning solutions.
A single application of 2000 mg/kg of neat Dowfax 3B2 was applied to the clipped tnmks of two male New Zealand White rabbits under an impervious, occlusive bandage Erythema, edema and burns were observed, at the application site, immediately after removing the wrap. These observations were observed through test day four. By test day eight, both animals were observed with scaling, which persisted through the end of the study. Both animals survived the test period at the 2000 mg/kg dose level. The estimated acute dermal LD50 for male New Zealand White rabbits was greater than 2000 mg/kg.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- acceptable
Additional information
In the key studies conducted with the REACH-registered substance, the acute oral and dermal toxicity were low, with an oral LD50 value of 1500 - 2000 mg/kg, and dermal LD50 value >2000 mg/kg (for the latter study, no deaths were observed). This is also true for the other ADPODS substances relevant for read across, indicating that this particular chemistry has a low order of acute toxicity via the oral and dermal routes.
No data are available for inhalation toxicity. However, this is unlikely to be a relevant route for human exposure due to the low vapor pressure and limited possibility for generating a large concentration of aerosol in normal handling conditions.
Justification for selection of acute toxicity – oral endpoint
acceptable limit dose study for the REACH-registered substance
Justification for selection of acute toxicity – dermal endpoint
acceptable limit dose study for the REACH-registered substance
Justification for classification or non-classification
Acute oral category 4 is required for Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate] according to CLP GHS. No dermal classification is required for the registered substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.