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EC number: 244-449-2 | CAS number: 21573-31-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-07-18 to 2017-07-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all test concetrations and control
- Sampling method: Another solution sampled separately from the preparation container (at the preparation). The mixed solution taken out with equal volume from the middle layer of the test solution in test vessels in each test level (before the renewal and at the end of exposure). - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test sample (50.0 mg) and dilution water processing similar to the control (471 mL) were mixed and stirred to prepare the stock solution of 100 mg/L. Required volumes of the stock solution and dilution water processing similar to the control were mixed and stirred in a preparing container to prepare the test solution which was divided into each test vessel. This preparation was carried out at the start of exposure and renewal of test solution.
- Controls: Dilution water filtered with a membrane filter (GV, 0.22 µm pore size, Millipore) by suction.
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): No - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Common water flea
- Strain/clone: Clone A
- Source: The University of Sheffield, UK
- Age of parental stock (mean and range, SD): 20 days
- Feeding during test: No
ACCLIMATION
- Acclimation period: Less than 24 hours.
- Acclimation conditions (same as test or not): Yes
- Type and amount of food: Chlorella vulgaris of 0.1 - 0.2 mg C (Organic carbon content)/day per Daphnia was fed.
- Feeding frequency: Once a day.
- Health during acclimation (any mortality observed): No. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 19.9 - 20.0°C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 7.0 - 8.3 mg/L
- Nominal and measured concentrations:
- Nominal: Control (0), 0.854, 1.88, 4.13, 9.09 and 20.0 mg/L
Measured:- Details on test conditions:
- TEST SYSTEM
- Test vessel: Autoclaved 50 mL stoppered Erlenmeyer flask (closed vessel)
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: 50 mL
- Aeration: No.
- Renewal rate of test solution (frequency/flow rate): Each 24 hours.
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water filtered with a membrane filter (GV, 0.22 µm pore size, Millipore) by suction.
- Total organic carbon: < 0.5 mg/L
- Alkalinity: 36 mg/L
- Ca/mg ratio: 32 mg/L
- Conductivity: 13 mS/m
- Culture medium different from test medium: No.
OTHER TEST CONDITIONS
- Adjustment of pH: No.
- Photoperiod: Room light, 16-hour light/8-hour dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Immobility
RANGE-FINDING STUDY
- Test concentrations: 1 and 10 mg/L
- Results used to determine the conditions for the definitive study: Yes.- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.24 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: In the 4.13, 9.09 and 20.0 mg/L test level, immobility, lethargy and reduced activity was observed.
- Mortality of control: No.
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No, difference between nominal and measured concentrations is < 20%.- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels: 48h-EC50 = 0.15 mg/LTable 1: Immobility
Nominal
concentration
(mg/L)
Vessel
24 hours
48 hours
Number of immobilized
daphnids/Total daphnids
Immobility
(%)
Number of immobilized
daphnids/Total daphnids
Immobility
(%)
Control
A
0 / 5
0
0 / 5
0
B
0 / 5
0 / 5
C
0 / 5
0 / 5
D
0 / 5
0 / 5
0.854
A
0 / 5
0
0 / 5
0
B
0 / 5
0 / 5
C
0 / 5
0 / 5
D
0 / 5
0 / 5
1.88
A
0 / 5
0
0 / 5
0
B
0 / 5
0 / 5
C
0 / 5
0 / 5
D
0 / 5
0 / 5
4.13
A
0 / 5
0
1 / 5
15
B
0 / 5
1 / 5
C
0 / 5
1 / 5
D
0 / 5
0 / 5
9.09
A
0 / 5
5
3 / 5
45
B
0 / 5
2 / 5
C
1 / 5
2 / 5
D
0 / 5
2 / 5
20.0
A
5 / 5
95
5 / 5
100
B
4 / 5
5 / 5
C
5 / 5
5 / 5
D
5 / 5
5 / 5
Table 2: Dissolved oxygen concentration of test solutions
Nominal
concentration
(mg/L)
At the start
24 hours
At the end
Before the
renewal
After the
renewal
Control
7.9
7.8
7.8
7.0
0.854
8.0
7.8
7.9
7.4
1.88
7.9
7.8
7.9
7.3
4.13
7.9
7.8
8.0
7.4
9.09
7.9
7.9
8.1
7.5
20.0
8.0
8.0
8.3
7.8
Table 3: pH of test solutions
Nominal
concentration
(mg/L)
At the start
24 hours
At the end
Before the
renewal
After the
renewal
Control
7.8
7.8
7.9
7.8
0.854
7.8
7.8
7.9
7.8
1.88
7.8
7.9
7.9
7.8
4.13
7.8
7.9
7.9
7.9
9.09
7.8
7.9
7.9
7.9
20.0
7.9
7.9
7.9
7.9
Table 4: Temperature in test solutions
Nominal
concentration
(mg/L)
At the start
24 hours
At the end
Before the
renewal
After the
renewal
Control
19.9
20.0
19.9
20.0
0.854
19.9
20.0
19.9
20.0
1.88
19.9
20.0
19.9
20.0
4.13
20.0
20.0
19.9
19.9
9.09
20.0
20.0
19.9
19.9
20.0
20.0
20.0
19.9
19.9
Table 5: Measured concentration of the test item in test solutions
Nominal
concentration
(mg/L)
Measured concentration (mg/L)
(Percentage of measured concentration versus nominal concentration %)
At the start
24 hours
At the end
Geometric mean
Before the renewal
After the renewal
Control
n.d.
n.d.
n.d.
n.d.
0.854
0.815
(95.4)
0.855
(100)
0.822
(96.3)
0.810
(94.9)
0.825
(96.7)
1.88
1.83
(97.2)
2.01
(107)
1.83
(97.5)
1.94
(103)
1.90
(101)
4.13
4.30
(104)
4.23
(103)
3.82
(92.4)
3.95
(95.7)
4.07
(98.6)
9.09
9.51
(105)
8.77
(96.5)
8.99
(98.9)
8.67
(95.4)
8.98
(98.8)
20.0
20.7
(104)
22.7
(113)
20.2
(101)
19.8
(99.2)
20.8
(104)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 (48h) of 7-Octen-1-al was determined as 8.24 mg/L based on nominal concentration.
- Executive summary:
The toxicity of 7-Octen-1-al on aquatic invertebrates was determined according to OECD 202 and in compliance with GLP. Individuals of Daphnia magna were exposed to the test substance in concentrations of 0 (control), 0.854, 1.88, 4.13, 9.09 and 20.0 mg/L, equivalent to <LOQ, 0.825, 1.90, 4.07, 8.98 and 20.8 mg/L measured concentrations, for 48 hours. Concentrations were analytically verified by GC-FID and were < 20% of the nominal concentrations. Immobility on Daphnids after 48 hours exposure were observed in the 4.13, 9.09 and 20 mg/L test levels. The 48h-EC50 was determined as 8.24 mg/L based on nominal concentration.
Reference
Description of key information
EC50 (48h) = 8.24 mg/L based on nominal concentration
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 8.24 mg/L
Additional information
The toxicity of 7-Octen-1-al on aquatic invertebrates was determined according to OECD 202 and in compliance with GLP. Individuals of Daphnia magna were exposed to the test substance in concentrations of 0 (control), 0.854, 1.88, 4.13, 9.09 and 20.0 mg/L, equivalent to <LOQ, 0.825, 1.90, 4.07, 8.98 and 20.8 mg/L measured concentrations, for 48 hours. Concentrations were analytically verified by GC-FID and were < 20% of the nominal concentrations. Immobility on Daphnids after 48 hours exposure were observed in the 4.13, 9.09 and 20 mg/L test levels. The 48h-EC50 was determined as 8.24 mg/L based on nominal concentration.
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